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Genome wide identification of scavenger receptors class A in common carp (Cyprinus carpio) and their expression following Aeromonas hydrophila infection

文献类型： 外文期刊

作者： Feng, Shuaisheng 1 ; Jiang, Yanliang 1 ; Zhang, Songhao 1 ; Dong, Chuanju 1 ; Jiang, Likun 1 ; Peng, Wenzhu 1 ; Mu, Xi 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Ctr Appl Aquat Genom, Key Lab Aquat Genom, Beijing, Peoples R China

2.Chinese Acad Fishery Sci, Ctr Appl Aquat Genom, Beijing Key Lab Fishery Biotechnol, Beijing, Peoples R China

3.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai, Peoples R China

4.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Lab Trop & Subtrop Fishery Resource Applicat & Cu, Minist Agr, Guangzhou, Guangdong, Peoples R China

关键词： Scavenger receptors class A; Common carp; SCARA; Immune response; Bacterial infection

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）

ISSN： 1050-4648

年卷期： 2016 年 54 卷

页码：

收录情况： SCI

摘要： Scavenger receptors class A (SCARAs) is a subgroup of diverse families of pattern recognition receptors that bind a range of ligands, and play important roles in innate immune processes through pathogens detection, adhesion, endocytosis, and phagocytosis. However, most studies of SCARAs have focused on mammals, and much less is known of SCARAs in fish species. In this study, we identified 7 SCARAs across the common carp genome, which were classified into four subclasses according to comparative genomic analysis including sequence similarities analysis, gene structure and functional domain prediction. Further phylogenetic and syntenic analysis supported their annotation and orthologies. Through examining gene copy number of SCARA genes across several vertebrates, SCARA2, SCARA3 and SCARA4 were found have undergone gene duplication. The expression patterns of SCARAs in common carp were examined during early developmental stages, in healthy tissues, and after Aeromonas hydrophila infection. Most SCARA genes were ubiquitously expressed during common carp early developmental stages, and presented diverse patterns in various healthy tissues, with relatively high expression levels in spleen, liver, intestine, gill and brain, indicating their critical roles likely in maintaining homeostasis and host immune response activities. After A. hydrophila infection, most SCARA genes were up-regulated at 4 h post infection in mucosal tissue intestine, while generally up-regulated at 12 h post infection in spleen, suggesting a tissue-specific pattern of regulation. Taken together, all these results suggested that SCARA genes played important roles in host immune response to A. hydrophila infection in common carp, and provided important genomic resources for future studies on fish disease management. (C) 2016 Elsevier Ltd. All rights reserved.

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