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Environmental and human health risks of antimicrobials used in Fenneropenaeus chinensis aquaculture production in China

文献类型： 外文期刊

作者： Sun, Ming 1 ; Chang, Zhiqiang 2 ; Van den Brink, Paul J. 3 ; Li, Jian 2 ; Zhao, Fazhen 2 ; Rico, Andreu 3 ;

作者机构： 1.Ocean Univ China, Fishery Coll, Qingdao 266003, Peoples R China

2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Minist Agr, Key Lab Sustainable Dev Marine Fisheries, Qingdao 266071, Peoples R China

3.Univ Wageningen & Res Ctr, Alterra, POB 47, NL-6700 AA Wageningen, Netherlands

4.Univ Wageningen & Res Ctr, Wageningen Univ, Dept Aquat Ecol & Water Qual Management, POB 47, NL-6700 AA Wageningen, Netherlands

5.Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, 1 Wenhai Rd, Qingdao, Peoples R China

6.Univ Alcala De Henares, IMDEA Water Inst, Sci & Technol Campus,Ave Punto Com 2,POB 28805, Madrid, Spain

关键词： Aquaculture; Human health; Ecological risk assessment; Shrimps; Environmental modelling; Antimicrobial resistance

期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH （ 影响因子：4.223； 五年影响因子：4.306 ）

ISSN： 0944-1344

年卷期： 2016 年 23 卷 15 期

页码：

收录情况： SCI

摘要： This study aimed to quantify the environmental fate of antimicrobials applied in Fenneropenaeus chinensis aquaculture production in China and to assess their potential risks for surrounding aquatic ecosystems, for the promotion of antimicrobial resistance in target and non-target bacteria and for consumers eating shrimp products that contain antimicrobial residues. For this, we first used the results of an environmental monitoring study performed with the antimicrobial sulfamethazine to parameterize and calibrate the ERA-AQUA model, a mass balance model suited to perform risk assessments of veterinary medicines applied in aquaculture ponds. Next, a scenario representing F. chinensis production in China was built and used to perform risk assessments for 21 antimicrobials which are regulated for aquaculture in China. Results of the model calibration showed a good correspondence between the predicted and the measured sulfamethazine concentrations, with differences within an order of magnitude. Results of the ecological risk assessment showed that four antimicrobials (levofloxacin, sarafloxacin, ampicillin, sulfadiazine) are expected to have adverse effects on primary producers, while no short-term risks were predicted for invertebrates and fish exposed to farm wastewater effluents containing antimicrobial residues. Half of the evaluated antimicrobials showed potential to contribute to antimicrobial resistance in bacteria exposed to pond water and farm effluents. A withdrawal period of three weeks is recommended for antimicrobials applied via oral administration to F. chinensis in order to comply with the current national and international toxicological food safety standards. The results of this study indicate the need to improve the current regulatory framework for the registration of aquaculture antimicrobials in China and suggest compounds that should be targeted in future aquaculture risk assessments and environmental monitoring studies.

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