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Absorption and pharmacokinetic study of two sulphated triterpenoid saponins in rat after oral and intravenous administration of saponin extracts of Pearsonothuria graeffei by HPLC-MS

文献类型： 外文期刊

作者： Song, Shanshan 1 ; Cong, Peixu 1 ; Xu, Jie 1 ; Li, Guoyun 2 ; Liu, Xiaofang 3 ; Li, Zhaojie 1 ; Xue, Changhu 1 ; Xue, Yon 1 ;

作者机构： 1.Ocean Univ China, Food Sci & Engn Coll, Qingdao 266003, Peoples R China

2.Ocean Univ China, Pharmaceut Sci Coll, Qingdao 266003, Peoples R China

3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Div Food Engn & Nutr, Qingdao 266003, Peoples R China

关键词： Sea cucumber; Saponins; Echinoside A; Holothurin A; Pharmacokinetic; HPLC-MS

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 2020影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2016 年 25 卷

页码：

收录情况： SCI

摘要： Echinoside A (EA) and holothurin A (HA) are the major saponins found in sea cucumbers. Their pharmacokinetics were studied following intravenous and oral administration of saponin extracts in rats. The serum and liver of rat were pretreated by protein precipitation and performed on ENVI-18 SPE cartridges. The compounds were analyzed by using a high-performance liquid chromatography mass spectrometry (HPLC-MS) method in the single ion monitoring (SIM) mode. The results demonstrated that serum EA concentration rapidly reduced in 5 min after intravenous administration. HA serum concentration reduced to its lowest level after 1 h. After oral administration, EA reached its peaks at 3 h and 7 h. The first peak of HA occurred at 3 h and reached a second peak at 9 h. In the liver, there were two peaks for EA at 2 h and 9 h, and only one peak for HA at 9 h. (C) 2016 Elsevier Ltd. All rights reserved.

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