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Four C1q domain-containing proteins involved in the innate immune response in Hyriopsis cumingii

文献类型： 外文期刊

作者： Zhao, Ling-Ling 1 ; Jin, Min 4 ; Li, Xin-Cang 5 ; Ren, Qian 2 ; Lan, Jiang-Feng 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

2.Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Biodivers & Biotechnol, Nanjing 210046, Jiangsu, Peoples R China

3.Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Aquat Crustacean Dis, Nanjing 210046, Jiangsu, Peoples R China

4.SOA, Inst Oceanog 3, State Key Lab Breeding Base Marine Genet Resource, Xiamen 361005, Peoples R China

5.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

6.Zhejiang Univ, Minist Agr, Key Lab Anim Virol, Hangzhou 310058, Zhejiang, Peoples R China

7.Zhejiang Univ, Coll Life Sci China, Hangzhou 310058, Zhejiang, Peoples R China

关键词： C1qDC protein; Bacterial binding; Hyriopsis cumingii; Innate immunity

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）

ISSN： 1050-4648

年卷期： 2016 年 55 卷

页码：

收录情况： SCI

摘要： C1q is a key subcomponent of the complement Cl complex. This subcomponent contains a globular C1q (gC1q) domain with remarkable ligand binding properties. C1q domain-containing (C1qDC) proteins are composed of all proteins with a gC1q domain. Cl qDC proteins exist in many invertebrates and recognize non-self-ligands. In our study, four C1qDC genes, namely, HcC1qDC1-HcC1qDC4, were identified from Hyriopsis cumingii. HcC1qDC1-HcC1qDC4 encode a protein of 224, 204, 305, and 332 amino acids, respectively. All Cl qDC proteins consist of a gC1q domain at the C terminal. In addition to the gC1q domain, a coiled-coil region is found in HcC1qDC4. Multiple alignments and phylogenetic tree analysis revealed that the Cl qDC proteins highly differ from one another. Tissue distribution analysis demonstrated that HcC1qDC1-HcClqDC4 are widely distributed in hemocytes, hepatopancreas, gills, mantle, and foot. These ClqDC genes are regulated by bacteria to varying degrees. These recombinant HcC1 qDC proteins exhibit a binding activity against different bacterial species. Our results may suggest the roles of HcC1 qDC genes in anti-bacterial immune defense. (C) 2016 Elsevier Ltd. All rights reserved.

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