Identification and expression analysis of TLR2 in mucosal tissues of turbot (Scophthalmus maximus L.) following bacterial challenge
文献类型： 外文期刊
作者： Liu, Fengqiao 1 ; Su, Baofeng 2 ; Gao, Chengbin 1 ; Zhou, Shun 1 ; Song, Lin 1 ; Tan, Fenghua 4 ; Dong, Xiaoyu 1 ; Ren, Y 1 ;
作者机构： 1.Qingdao Agr Univ, Marine Sci & Engn Coll, Qingdao 266109, Peoples R China
2.Chinese Acad Fishery Sci, Heilongjiang Fisheries Res Inst, Minist Agr, Key Lab Freshwater Aquat Biotechnol & Breeding, Harbin 150070, Peoples R China
3.Chinese Acad Fishery Sci, Natl & Local Joint Engn Lab Freshwater Fish Breed, Heilongjiang Fisheries Res Inst, Harbin 150070, Peoples R China
4.Qingdao Agr Univ, Sch Int Educ & Exchange, Qingdao 266109, Peoples R China
关键词： TLR2; Mucosal tissues; Scophthalmus maximus; Vibrio anguillarum; Streptococcus iniae
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）
ISSN： 1050-4648
年卷期： 2016 年 55 卷
页码：
收录情况： SCI
摘要： The pathogen recognition receptors (PRRs), which can recognize the conserved pathogen-associated molecular patterns (PAMPs) of the bacteria, play key roles in the mucosal surfaces for pathogen recognition and activation of immune signaling pathways. However, our understanding of the PRRs and their activities in mucosal surfaces in the critical early time points during pathogen infection is still limited. Towards to this end, here, we sought to identify the Toll-like receptor 2 (TLR2) in turbot as well as its expression profiles in mucosal barriers following bacterial infection in the early time points. The fulllength TLR2 transcript consists of open reading frame (ORF) of 2451 bp encoding the putative peptide of 816 amino acids. The phylogenetic analysis revealed the turbot TLR2 showed the closest relationship to Paralichthys olivaceus. The TLR2 mRNA expression could be detected in all examined tissues, with the most abundant expression level in liver, and the lowest expression level in skin. In addition, TLR2 showed different expression patterns following Vibrio anguillarum and Streptococcus iniae infection, but was up regulated following both challenge, especially post S. iniae challenge. Characterization of TLR2 will probably contribute to understanding of a number of infectious diseases and broaden the knowledge of interactions between host and pathogen, which will eventually help in the development of novel intervention strategies for farming turbot. (C) 2016 Elsevier Ltd. All rights reserved.
- 相关文献
作者其他论文 更多>>
-
Environmental impacts of deep offshore aquaculture on potential harmful elements in sediment: A case study of Deep Blue I in the yellow sea cold water mass
作者：Yu, Yu;Qu, Lingling;Wang, Yi;Ren, Yichao;Wang, Bowen;Li, Li;Meng, Xianliang
关键词：Offshore cage; Salmon culture; Trace element; Copper; South yellow sea
-
Population Pharmacokinetics of Enrofloxacin in Ctenopharyngodon idella Based on the Sparse Sampling Method and a Nonlinear Mixed Effect Model Following Intravenous and Oral Administration
作者：Xu, Ning;Zhang, Huan;Zhou, Shun;Liu, Yongtao;Yang, Qiuhong;Dong, Jing;Ai, Xiaohui;Xu, Ning;Zhou, Shun;Liu, Yongtao;Yang, Qiuhong;Dong, Jing;Ai, Xiaohui;Zhang, Huan;Ding, Yongzhen
关键词：bioavailability; enrofloxacin; grass carp; population pharmacokinetics
-
Chromosome-level genome assembly and annotation of the White-spotted spinefoot Siganus canaliculatus
作者：Huang, Xiaolin;Xian, Lin;Yang, Yukai;Zhang, Dianchang;Huang, Xiaolin;Xian, Lin;Yang, Yukai;Zhang, Dianchang;Huang, Xiaolin;Yang, Yukai;Zhang, Dianchang;Lu, Yanke;Zhang, Hui;Huang, Shiting;Wang, Lei;Li, Chao;Xian, Lin
关键词：
-
Population Pharmacokinetics of Enrofloxacin in Micropterus salmoides Based on a Nonlinear Mixed Effect Model After Intravenous and Oral Administration
作者：Xu, Ning;Zhou, Shun;Dong, Jing;Li, Jiangtao;Ai, Xiaohui;Xu, Ning;Ding, Yongzhen
关键词：enrofloxacin; population pharmacokinetics; statistical approaches; largemouth bass; body weight
-
Haplotype resolved chromosome-level genome assembly of the gold barb (Barbodes semifasciolatus)
作者：Chen, Weitao;Li, Yuefei;Li, Jie;Chen, Weitao;Li, Yuefei;Li, Jie;Chen, Weitao;Li, Yuefei;Li, Jie;Li, Chao;Yang, Rong;Wu, Baosheng
关键词：
-
Preclinical Evaluation of Fenbendazole for Controlling Gyrodactylus kobayashii (Monogenea, Gyrodactylidae) in Goldfish: Dose Optimization and Safety Assessment
作者：Dong, Jing;Li, Jiangtao;Liu, Yongtao;Yang, Qiuhong;Xu, Ning;Ai, Xiaohui;Zhou, Shun;Dong, Jing
关键词：preclinical study; fenbendazole; monogenean; anthelmintic treatment; aquaculture
-
Genome-Wide Identification and Expression Analysis of Zona Pellucida (ZP) Gene Family in Cynoglossus semilaevis
作者：Zhang, Kaili;Sha, Zhenxia;Chen, Songlin;Zhang, Kaili;Chen, Zhangfan;Gao, Chengbin;Li, Xihong;Wang, Na;Zhang, Min;Yan, Haipeng;Chen, Songlin;Chen, Zhangfan;Gao, Chengbin;Li, Xihong;Wang, Na;Chen, Songlin
关键词：zona pellucida;
Cynoglossus semilaevis ; expression profiles; fertilization; oogenesis
