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Quantitative Label-Free Proteomic Analysis of Milk Fat Globule Membrane in Donkey and Human Milk

文献类型： 外文期刊

作者： Zhang, Xinhao 1 ; Jiang, Bo 3 ; Ji, Chuanliang 2 ; Li, Haijing 2 ; Yang, Li 2 ; Jiang, Guimiao 2 ; Wang, Yantao 2 ; Liu, 1 ;

作者机构： 1.Shandong Agr Univ, Coll Anim Sci & Technol, Tai An, Shandong, Peoples R China

2.Dong EE Jiao Co Ltd, Natl Engn Res Ctr Gelatin Based Tradit Chinese Me, Liaocheng, Shandong, Peoples R China

3.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing, Peoples R China

4.Liaocheng Univ, Shandong Donkey Ind, Technol Collaborat Innovat Ctr, Liaocheng, Shandong, Peoples R China

5.Qingdao Agr Univ, Coll Anim Sci & Technol, Qingdao, Peoples R China

关键词： human; donkey; quantitative proteomic; comparison; milk fat globule membrane

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.576； ）

ISSN： 2296-861X

年卷期： 2021 年 8 卷

页码：

收录情况： SCI

摘要： Previous studies have found donkey milk (DM) has the similar compositions with human milk (HM) and could be used as a potential hypoallergenic replacement diet for babies suffering from cow's milk allergy. Milk fat globule membrane (MFGM) proteins are involved in many biological functions, behaving as important indicators of the nutritional quality of milk. In this study, we used label-free proteomics to quantify the differentially expressed MFGM proteins (DEP) between DM (in 4-5 months of lactation) and HM (in 6-8 months of lactation). In total, 293 DEP were found in these two groups. Gene Ontology (GO) enrichment analysis revealed that the majority of DEP participated in regulation of immune system process, membrane invagination and lymphocyte activation. Several significant Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were determined for the DEP, such as lysosome, galactose metabolism and peroxisome proliferator-activated receptor (PPAR) signaling pathway. Our study may provide valuable information in the composition of MFGM proteins in DM and HM, and expand our knowledge of different biological functions between DM and HM.

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