文献类型： 外文期刊
作者： Hu, Zhongchang 1 ; Wu, Jian 1 ; Qin, Lihong 1 ; Jin, Haiguo 1 ; Cao, Yang 1 ; Zhao, Yumin 1 ;
作者机构： 1.Jilin Acad Agr Sci, Branch Anim Husb, 186 Dongxinghua Rd, Gongzhuling 136100, Peoples R China
2.Minist Agr & Rural Agr, Key Lab Beef Cattle Genet & Breeding, Gongzhuling, Peoples R China
关键词： IGFBP7; adipogenesis; lipid accumulation; triglyceride
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）
ISSN： 1049-5398
年卷期：
页码：
收录情况： SCI
摘要： The insulin-like growth factor binding-protein 7 (IGFBP7) has binding affinities to IGFs and is able to either positively or negatively regulate the IGFs signaling pathway. It also plays a crucial role in cell growth, differentiation and development in an IGF-independent manner. Herein, we investigated the specific regulation of the gene encoding for IGFBP7during the differentiation process of the adipocyte cells of the Yan Yellow Cattle by interfering with or by overexpressing the IGFBP7 gene. As a result, we found that the mRNA expression levels of IGFBP7 were significantly increased during the formation of progenitor cells. In addition, the expression levels of the lipoprotein lipase (LPL) and transcription factors (PPAR gamma, C/EBP alpha) were also significantly increased. IGFBP7 gene overexpression and RNA interfering promoted and inhibited respectively the lipid accumulation and triglyceride production in mature adipocytes, and the expression of the LPL and transcription factors (PPAR gamma, C/EBP alpha). The changes in the protein expression levels of IGFBP7 and adipogenic factors were in accord with the changes observed in the mRNA levels. In conclusion, our results indicate that IGFBP7 plays an important regulatory role in the differentiation of preadipocyte cells.
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