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Relationship between the CUBN and the MIA3 gene copy number variation and growth traits in different cattle breeds

文献类型： 外文期刊

作者： Han, Yue 1 ; Liu, Jiwei 1 ; Zhang, Congcong 1 ; Sun, Ming 1 ; Li, Xuanyu 1 ; Liu, Hongliang 1 ; Li, Shengnan 1 ; Zhu, Yongchao 1 ; Li, Ruidong 1 ; Luo, Xiaotong 1 ; Zhao, Yumin 1 ; Wu, Jian 1 ;

作者机构： 1.Jilin Acad Agr Sci, Changchun, Jilin, Peoples R China

2.Minist Agr & Rural Affairs, Key Lab Beef Cattle Genet & Breeding, Changchun, Jilin, Peoples R China

3.Jilin Prov Beef Cattle Breeding Innovat Ctr, Changchun, Jilin, Peoples R China

4.Jilin Prov Beef Cattle Performance Testing Stn, Changchun, Jilin, Peoples R China

5.Jilin Prov Beef Cattle Breeding & Breeding Technol, Changchun, Jilin, Peoples R China

6.Jilin Prov Int Joint Res Ctr Meat & Grass Eating L, Changchun, Jilin, Peoples R China

关键词： Grassland red cattle; yanbian cattle; yan Yellow cattle; intrinsic factor-cobalamin receptor; MIA SH3 domain ER-derived factor 3; copy number variations

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：1.8； 五年影响因子：2.0 ）

ISSN： 1049-5398

年卷期： 2025 年 36 卷 1 期

页码：

收录情况： SCI

摘要： Copy number variations (CNV) are important genetic variations. The endogenous factors cobalamin receptor (CUBN) and MIA SH3 domain ER-derived factor 3 (MIA3) are associated with bone/muscle development and intramuscular fat deposition. There have been no reports on the effects of CUBN and MIA3 CNVs on growth traits of Chinese cattle. This study aimed to determine the correlation between the CUBN and MIA3 CNVs and growth traits in Chinese cattle. qRT-PCR was used to detect the distribution of CUBN and MIA3 CNV and the expression levels of their mRNA, and correlation analysis was conducted between CNV and growth traits. The CUBN was differentially expressed in different breeds of cattle, and CUBN CNV correlated significantly with body height, hip height, body slanting length, and hip width of Grassland Red cattle (CYH); eye muscle area of Yanbian cattle (YB) and Yan Yellow cattle (YH). MIA3 showed no CNV in CYH and YB cattle, and only one deletion type occurred in YH cattle. CUBN and MIA3 mRNA have different expression patterns in different cattle breeds and tissues. In conclusion, CUBN CNV is correlated significantly with growth traits in Chinese cattle and is a novel molecular marker that could be exploited in cattle breeding.

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