Tissue residue depletion kinetics and withdrawal time estimation of doxycycline in grass carp, Ctenopharyngodon idella, following multiple oral administrations
文献类型： 外文期刊
作者： Xu, Ning 1 ; Li, Miao 2 ; Fu, Yu 3 ; Zhang, Xiaomei 4 ; Ai, Xiaohui 1 ; Lin, Zhoumeng 2 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, 8 Wuda Pk Rd 1, Wuhan 430223, Hubei, Peoples R China
2.Kansas State Univ, Coll Vet Med, Dept Anat & Physiol, ICCM, 1800 Denison Ave,P200 Mosier Hall, Manhattan, KS 66506 USA
3.Hunan Univ Arts & Sci, Changde 415000, Peoples R China
4.Hunan Appl Technol Univ, Changde 415000, Peoples R China
5.Hu Bei Prov Engn & Technol Res Ctr Aquat Prod Qua, Wuhan 430223, Hubei, Peoples R China
关键词： Doxycycline; Grass carp; Withdrawal time; Tissue residue; Food safety; Tolerance limit method
期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）
ISSN： 0278-6915
年卷期： 2019 年 131 卷
页码：
收录情况： SCI
摘要： This study aimed to determine the plasma and tissue residue depletion kinetics of doxycycline (DC) in grass carp (Ctenopharyngodon idella) after daily oral administrations at 20 mg/kg for 3 days, and to calculate the corresponding withdrawal times. Following drug administrations, samples of plasma, liver, kidney, gill and muscle + skin were collected at predetermined time points (0.25, 0.5, 1, 3, 5, 7, 14, 21, 28, 35, 42, 49 and 56 days) and analyzed for concentrations of DC using a LC-MS/MS method. The results showed that liver had the highest concentrations and the slowest depletion compared to other tissues, with detectable DC up to 49 days (58.9 +/- 12.8 mu g/kg). The WT 1.4 software and "reschem" package were used to calculate withdrawal times, and the results were similar. The results suggest a withdrawal time of 41 days for Europe and China and 50 days for Japan is needed for DC in grass carp after 3 daily oral administrations at 20 mg/kg. Overall, this study improves our understanding of the tissue residue depletion kinetics of DC in fish, and the results may help regulatory agencies to determine proper withdrawal periods based on different regulatory standards in different countries to ensure safety of aquatic food products.
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