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Biological activity evaluation and action mechanism of 1,4-Pentadien-3-one derivatives containing thiophene sulfonate

文献类型： 外文期刊

作者： Guo, Tao 1 ; Xia, Rongjiao 1 ; Chen, Mei 1 ; Su, Shijun 1 ; He, Jun 1 ; He, Ming 1 ; Wang, Hua 2 ; Xue, Wei 1 ;

作者机构： 1.Guizhou Univ, Ctr Res & Dev Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Guizhou, Peoples R China

2.Hubei Acad Agr Sci, Inst Plant Protect & Soil Fertilizer, Wuhan 430064, Hubei, Peoples R China

关键词： Thiophene sulfonate; 1,4-pentadien-3-one; antibacterial activities; scanning electron microscopy

期刊名称：PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS （ 影响因子：1.082； 五年影响因子：0.859 ）

ISSN： 1042-6507

年卷期：

页码：

收录情况： SCI

摘要： A series of novel 1,4-pentadien-3-one derivatives containing a thiophene sulfonate group were designed, synthesized, and their antibacterial activities were assessed. Antibacterial bioassays indicated that some of the title compounds exerted significant bioactivities against Xanthomonas axonopodis pv. Citri (Xac), Ralstonia solanacearum (Rs) and Xanthomonas oryzae pv. Oryzae (Xoo). Especially for Xac, the value of minimum 50% effective concentration (EC50) of compound 4-((1E,4E)-5-(3-nitrophenyl)-3-oxopenta-1,4-dien-1-yl)phenylthiophene-2-sulfonate (3k) is 11.0 mu g/mL, which is significantly superior to bismerthiazol (BT) (51.6 mu g/mL) and thiodiazole-copper (TC) (94.7 mu g/mL). Meanwhile, the mechanism of action of compound 3k was confirmed by using scanning electron microscopy (SEM). These results suggested that 1,4-pentadien-3-one derivatives containing thiophene sulfonate group may be considered as activators in the design of antibacterial agents.

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