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Phylogeny, pathogenicity and transmissibility of a genotype XII Newcastle disease virus in chicken and goose

文献类型： 外文期刊

作者： Xiang, Bin 1 ; Chen, Ruojin 1 ; Liang, Jianpeng 1 ; Chen, Libin 1 ; Lin, Qiuyan 1 ; Sun, Minhua 5 ; Kang, Yinfeng 6 ; Din 1 ;

作者机构： 1.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China

2.Minist Agr, Key Lab Anim Vaccine Dev, Guangzhou, Guangdong, Peoples R China

3.Natl & Reg Joint Engn Lab Medicament Zoonosis Pre, Guangzhou, Guangdong, Peoples R China

4.Key Lab Zoonosis Prevent & Control Guangdong Prov, Guangzhou, Guangdong, Peoples R China

5.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangdong Open Lab Vet Publ Hlth, Guangzhou, Guangdong, Peoples R China

6.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Dept Expt Res,Canc Ctr, Guangzhou, Peoples R China

7.CAAS, Shanghai Vet Res Inst SHVRI, Shanghai, Peoples R China

关键词： genotype XII; Newcastle disease virus; pathogenicity; phylogeny; transmissibility

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：5.005； 五年影响因子：4.622 ）

ISSN： 1865-1674

年卷期：

页码：

收录情况： SCI

摘要： Although Newcastle disease virus (NDV) has a worldwide distribution, some NDV genotypes have more regional geographical ranges within continents. In this study, we isolated a subgenotype XIIb NDV strain, Goose/CH/GD/E115/2017 (E115), from geese in Guangdong province, Southern China, in 2017. Phylogenetic analysis showed that E115 and six other NDVs from geese in China were grouped under subgenotype XIIb and were distinct from subgenotype XIIa, isolated from chickens in South Africa, and subgenotype XIId, isolated from chickens in Vietnam. To better understand the pathogenicity and transmission of the subgenotype XIIb NDVs from geese in Guangdong province, we inoculated chickens and geese with 10(6) EID50 of the E115 virus. Eight hours after inoculation, three naive chickens and three naive geese were co-housed with the infected chickens or geese to assess intraspecific and interspecific horizontal transmission of the E115 virus. The E115 virus induced significant clinical signs without mortality in chickens, while it was not pathogenic to geese. Intraspecific and interspecific horizontal transmission of the E115 virus was observed among chickens and geese via direct contact. Furthermore, although the current vaccines provided complete protection against disease in chickens after challenging them with the E115 virus, the virus could also be transmitted from vaccinated chickens to naive contact chickens. Collectively, our findings highlight the need for avoiding the mixing of different bird species to reduce cross-species transmission and for surveillance of NDV in waterfowl.

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