文献类型： 外文期刊
作者： Yu, Haiqian 1 ; Sperlich, Julia 2 ; Hoefert, Simon-Patrick 3 ; Janiak, Christoph 3 ; Teusch, Nicole 2 ; Stuhldreier 1 ;
作者机构： 1.Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany
2.TH Koln, Fac Appl Nat Sci, Biopharmaceut Chem & Mol Pharmacol, Chempk, D-51368 Leverkusen, Germany
3.Heinrich Heine Univ Dusseldorf, Inst Inorgan & Struct Chem, Univ Str 1, D-40225 Dusseldorf, Germany
4.Univ Osnabrueck, Fac Human Sci, Dept Biomed Sci, Barbarastr 22, D-49076 Osnabruck, Germany
5.Heinrich Heine Univ Dusseldorf, Inst Mol Med 1, Med Fac, Univ Str 1, D-40225 Dusseldorf, Germany
6.Heinrich Heine Univ Dusseldorf, Inst Pharmaceut & Med Chem, Univ Str 1, D-40225 Dusseldorf, Germany
7.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China
关键词： Coniella fragariae; Azaphilones; Pyrenophorin; Cytotoxicity
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2019 年 137 卷
页码：
收录情况： SCI
摘要： Two azaphilone pigments (1 and 2), two dihydrobenzofurans (3 and 4), two macrodiolides (5 and 6), and a dimeric alkyl aromatic constituent (7) were isolated from the goose dung-derived fungus Coniella fragariae. Compounds 1-3 proved to be new natural products. Coniellins H and I (1 and 2) feature a tetracyclic core and an aldehyde group at C-5, which is unusual for azaphilone derivatives. The X-ray structure of pyrenophorin (5) is reported for the first time. Pyrenophorin (5) showed strong cytotoxicity against several cancer cell lines with IC50 values ranging from 0.07 to 7.8 mu M.
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