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p-Terphenyl and Diphenyl Ether Derivatives from the Marine-Derived Fungus Aspergillus candidus HM5-4

文献类型： 外文期刊

作者： Zeng, Yanbo 1 ; Wang, Shirong 1 ; Peng, Hanyang 1 ; Zhao, Weibo 1 ; Chang, Wenjun 1 ; Wang, Hao 1 ; Chen, Huiqin 1 ; Dai, Haofu 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliza, Haikou 571101, Peoples R China

2.Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China

3.Agr Univ Hebei, Ocean Coll, Qinhuangdao 066000, Peoples R China

4.Chinese Acad Trop Agr Sci, Zhanjiang Expt Stn, Zhanjiang 524013, Peoples R China

5.Nanjing Univ Chinese Med, Jiangsu Key Lab Funct Subst Chinese Med, Nanjing 210023, Peoples R China

6.Beijing Inst Technol, Sch Life Sci, Beijing Key Lab Separat & Anal Biomed & Pharmaceut, Beijing 100081, Peoples R China

关键词： marine fungus; Aspergillus candidus; p-terphenyl; diphenyl ether; antifungal activity; cytotoxic activity; alpha-glucosidase inhibition

期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）

ISSN：

年卷期： 2024 年 22 卷 1 期

页码：

收录情况： SCI

摘要： Two undescribed p-terphenyl derivatives, asperterphenylcins A-B (1-2), and two undescribed diphenyl ether derivatives, asperdiphenylcins A-B (3-4), together with three previously described p-terphenyl derivatives-4 ''-deoxyterprenin (5), terphenyllin (6), and 3 ''-hydroxyterphenyllin (7)-were obtained from the solid-rice culture of the marine-derived fungus Aspergillus candidus HM5-4, which was isolated from sponges from the South China Sea. Their structures were elucidated by HRESIMS data and NMR spectroscopic analysis. Compound 1 showed a strong inhibitory effect on Neoscytalidium dimidiatum, with an inhibition circle diameter of 31.67 +/- 2.36 mm at a concentration of 10.0 mu g/disc. Compounds 5 and 7 displayed cytotoxic activity against human chronic myeloid leukemia cells (K562), human liver cancer cells (BEL-7402), human gastric cancer cells (SGC-7901), human non-small cell lung cancer cells (A549) and human HeLa cervical cancer cells, with IC50 values ranging from 3.32 to 60.36 mu M, respectively. Compounds 2, 6 and 7 showed potent inhibitory activity against alpha-glucosidase, with IC50 values of 1.26 +/- 0.19, 2.16 +/- 0.44 and 13.22 +/- 0.55 mu M, respectively.

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