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Dicaffeoylquinic acids from Ilex kudingcha attenuate dextran sulfate sodium-induced colitis in C57BL/6 mice in association with the modulation of gut microbiota

文献类型: 外文期刊

作者: Wan, Peng 1 ; Peng, Yujia 1 ; Chen, Guijie 1 ; Xie, Minhao 1 ; Dai, Zhuqing 1 ; Huang, Kaiyin 1 ; Dong, Wei 1 ; Zeng, Xia 1 ;

作者机构: 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

2.Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Sa, Nanjing 210023, Jiangsu, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Farm Prod Proc, Nanjing 210014, Jiangsu, Peoples R China

关键词: Ilex kudingcha; Dicaffeoylquinic acids; Colitis; Inflammation; Gut microbiota; Short-chain fatty acids

期刊名称:JOURNAL OF FUNCTIONAL FOODS ( 影响因子:4.451; 五年影响因子:4.907 )

ISSN: 1756-4646

年卷期: 2019 年 61 卷

页码:

收录情况: SCI

摘要: Kudingcha (KDC), one of herb teas in China, has been demonstrated to exhibit various health-promoting functions. In this study, the effects of dicaffeoylquinic acids (DiCQAs) from Ilex kudingcha on dextran sulfate sodium (DSS)-induced colitis and gut microbiota in mice were investigated. As results, DiCQAs could alleviate colitis disease activity index, colon shortening, colonic tissue inflammation and pro-inflammatory cytoldnes, and increase the level of SCFAs. Moreover, DiCQAs could modulate the gut microbiota, including increases of relative abundances of Odoribacter (from 0.06 +/- 0.01% to 0.26 +/- 0.05%) and PrevotelLa (from 0.54 +/- 0.03% to 1.75 +/- 0.04%), and decreases of relative abundances of Bacteroides (from 32.74 +/- 0.33% to 26.16 +/- 0.26%), Parasutterella (from 1.92 +/- 0.06% to 1.31 +/- 0.07%) and Lachnospiraceae (from 1.63 +/- 0.16% to 1.16 +/- 0.07%). The results suggested that DiCQAs could attenuate DSS-induced colitis which might be due to the alteration of the gut microbiota.

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