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Pig SOX9: Expression profiles of Sertoli cell (SCs) and a functional 18 bp indel affecting testis weight

文献类型： 外文期刊

作者： Chen, Mingyue 1 ; Wang, Jing 2 ; Liu, Nuan 1 ; Cui, Wenbo 1 ; Dong, Wuzi 1 ; Xing, Baosong 2 ; Pan, Chuanying 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Key Lab Anim Biotechnol,Minist Agr, Yangling 712100, Shaanxi, Peoples R China

2.Henan Acad Agr Sci, Henan Key Lab Farm Anim Breeding & Nutr Regulat, Inst Anim Husb & Vet Sci, 116 Huayuan Rd, Zhengzhou 450002, Henan, Peoples R China

关键词： Sex determining region Y-Box 9(SOX9); Reproduction; Indel; Sertoli cell (SC)

期刊名称：THERIOGENOLOGY （ 影响因子：2.74； 五年影响因子：2.93 ）

ISSN： 0093-691X

年卷期： 2019 年 138 卷

页码：

收录情况： SCI

摘要： Sex determining region Y box 9 (SOX9), an important member of the SRY- type HMGbox (SOX) gene family, plays an important role in the regulation of mammalian reproduction, including sex differentiation during the embryonic development stage and spermatogenesis after birth. To explore the roles of polymorphism and expression of the SOX9 gene in the development of testes, we analyzed the indel of SOX9 in pigs and the corresponding expression level of the SOX9 gene in 7-day and 5-month-old porcine Sertoli cells. Results revealed that the DD haplotype of SOX9 gene as well as the ID genotype were significantly associated with larger testicular weight, while the H haplotype was closely related to the smaller testicular weight. More importantly, the SOX9 gene expression of ID genotyped group was significantly higher than that in II genotyped group. Our results first revealed that the indel polymorphism and expression of SOX9 were significantly associated with pig reproduction traits indicating the critical roles of SOX9 gene in testes development. The study provides a new clue for understanding the regulation of animal reproductive activities. (C) 2019 Elsevier Inc. All rights reserved.

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