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Enhanced Chemical Stability, Intestinal Absorption, and Intracellular Antioxidant Activity of Cyanidin-3-O-glucoside by Composite Nanogel Encapsulation

文献类型： 外文期刊

作者： Feng, Jin 1 ; Wu, Yinghui 1 ; Zhang, Lixia 1 ; Li, Ying 1 ; Liu, Songbai 2 ; Wang, Hua 3 ; Li, Chunyang 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, 50 Zhongling St, Nanjing 210014, Jiangsu, Peoples R China

2.Zhejiang Univ, Dept Food Sci & Nutr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

3.Zhejiang Univ, Ctr Anal & Measurement, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

关键词： composite nanogel; cyanidin-3-O-glucoside; cellular uptake; monolayer permeability; intracellular antioxidant activity

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2019 年 67 卷 37 期

页码：

收录情况： SCI

摘要： A composite nanogel was developed for cyanidin-3-O-glucoside (C3G) delivery by combining Maillard reaction and heat gelation. The starting materials utilized were ovalbumin, dextran, and pectin. C3G-loaded nanogel was spherical with a diameter of similar to 185 nm, which was maintained over a wide range of pH and NaCl concentrations. The composite nanogel enhanced the chemical stability of C3G under accelerated degradation models and a simulated gastrointestinal tract. Clathrin-mediated, caveolae-mediated, and macropinocytosis-related endocytosis contributed to the higher cellular uptake of nano-C3G than that of free-C3G. The apparent permeability coefficients of C3G increased 2.16 times after nanoencapsulation. The transcytosis of the C3G-bearing nanogel occurred primarily through the clathrin-related pathway and macropinocytosis and followed the "common recycling endosomes-endoplasmic reticulum-Golgi complex-basolateral plasma membrane" route. Moreover, nano-C3G was more efficient in restoring the viability of cells and activities of endogenous antioxidant enzymes than free-C3G in oxidative models, which may be attributed to the former's high cellular absorption.

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