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Indigenous AHL-degrading bacterium Bacillus firmus sw40 affects virulence of pathogenic Aeromonas hydrophila and disease resistance of gibel carp

文献类型： 外文期刊

作者： Li, Miao-Yu 1 ; Xi, Bing-Wen 1 ; Qin, Ting 1 ; Chen, Kai 1 ; Ren, Ming-Chun 1 ; Xie, Jun 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Minist Agr, Key Lab Freshwater Fisheries & Germplasm Resource, Wuxi 214081, Jiangsu, Peoples R China

2.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi, Jiangsu, Peoples R China

关键词： Aeromonas hydrophila; AHL; antibiotic alternative; Bacillus firmus; quorum quenching

期刊名称：AQUACULTURE RESEARCH （ 影响因子：2.082； 五年影响因子：2.415 ）

ISSN： 1355-557X

年卷期：

页码：

收录情况： SCI

摘要： Interrupting quorum sensing represents a novel anti-infective strategy to combat bacterial pathogen, and biodegradation of quorum sensing signal AHLs has been proved to be an efficient way to control pathogenic Gram-negative bacteria in aquaculture. In this study, the effect of Bacillus firmus sw40 as efficient AHL-degrading strain on virulence of fish pathogen Aeromonas hydrophila and disease resistance of gibel carp Carassius auratus gibelio was investigated. The results demonstrated that in vitro the B. firmus sw40 extracellular production (ECP) was able to significantly decrease protease production, haemolytic activity and biofilm formation in A. hydrophila. Dietary administration of B. firmus sw40 (10(9) CFU/g) for 4 weeks significantly reduced the inflammatory cytokines TNF-1a, TNF-2a and IFN-gamma genes expression, antioxidant parameter MDA and GSH levels in serum and increased antioxidant enzyme SOD activity. Besides, B. firmus sw40 could significantly increase the survival of gibel carp with pathogenic A. hydrophila infection.

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