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Expression Profile of Sox5 and Sox6 in Sertoli and Spermatogonial Cells in Growing Mice Testis

文献类型： 外文期刊

作者： Rehman, Zia Ur 1 ; Liu, Qing 1 ; Bhattarai, Dinesh 1 ; Liang, Aixin 1 ; Ullah, Farman 4 ; Dad, Rahim 5 ; Khan, Sher Ba 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Educ Minist China, Wuhan 430070, Hubei, Peoples R China

2.Yandzhou Univ, Coll Anim Sci & Technol, Yanzhou 225000, Peoples R China

3.Univ Agr, Fac Anim Husb & Vet Sci, Dept Anim Hlth, Peshawar 2500, Pakistan

4.LUAWMS, Fac Anim Husb & Vet Sci, Las Bela 90150, Balochistan, Pakistan

5.Sindh Agr Univ, Fac Anim Husb & Vet Sci, Tandojam 70060, Pakistan

6.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangzhou 510640, Guangdong, Peoples R China

关键词： Sertoli cells; Spermatogenesis; Sox5; Sox6; Testis

期刊名称：KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI （ 影响因子：0.685； 五年影响因子：0.655 ）

ISSN： 1300-6045

年卷期： 2020 年 26 卷 1 期

页码：

收录情况： SCI

摘要： SRY box genes are peculiar to animal kingdom. They are involved in many processes particularly sex determination and testes development in male embryo. Although Sox family genes have been identified in various cells, their expression pattern and role is not entirely recognized in Sertoli cells. In this research, we focused on the expression of SoxD group Sox5 and Sox6 genes in Sertoli cells of mice during pre- and post-pubertal testicular development ranging from one-week-old to eight-week-old mice. The expression was studied by immunohistochemistry on whole testes, and qPCR to determine the mRNA level of all age groups, while immunocyto-chemistry was performed for localization in specific age groups. qPCR results of Sertoli cells from first week to eight week showed different levels of expression. The mRNA level of Sox5, during pre-pubertal age, was significantly high (P<0.001), but as the age progressed, the expression became low. Conversely, Sox6 was initially expressed faintly, but at the pubertal age, the expression rose significantly (P<0.001). Furthermore, the expression signals of both genes on spermatogonial cells were also found strong. The study shows that Sox5 and Sox6 are expressed during postnatal and pubertal periods and may play a vital role in the maturation of spermatozoa. In addition, they overlap to regulate multiple functions like spermatogenesis and steroidogenesis in testes.

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