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Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish

文献类型： 外文期刊

作者： Wu, Qin 2 ; Yan, Wei 1 ; Liu, Chunsheng 2 ; Hung, Tien-Chieh 3 ; Li, Guangyu 2 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Qual Stand & Testing Tedmol Agroprod, Wuhan 430064, Hubei, Peoples R China

2.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China

3.Univ Calif Davis, Dept Biol & Agr Engn, Davis, CA 95616 USA

4.Hubei Prov Engn Lab Pond Aquaculture, Wuhan 430070, Hubei, Peoples R China

关键词： Microcystin-LR; Titanium dioxide nanoparticles; Co-exposure; Oxidative stress

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：7.963； 五年影响因子：7.842 ）

ISSN： 0048-9697

年卷期： 2019 年 693 卷

页码：

收录情况： SCI

摘要： Owing to the eutrophication in freshwater and industrial emissions, the detected concentrations of MCLR and nano-TiO2 in nature water increase year by year. The purpose of this study was to evaluate the joint effect of microcystin-LR ( MCLR) and titanium dioxide nanoparticles (nano-TiO2) on the zebrafish brain and to investigate the underlying mechanisms. In this study, four-month old zebrafish were exposed to 0, 0.5, 4, and 32 mu g/L MCLR and MCLR-co-nano-TiO2 (100 mu g/L) for 45 days. Obvious brain injury characterized by formation of glial scars and ventriculomegaly was observed in both MCLR groups and MCLR-co-nano-TiO2 groups. In addition, our results showed the existence of nano-TiO2 aggravated MCLR-induced abnormity of swimming behavior and social behavior of zebrafish. To clarify the mechanisms of nano-TiO2 aggravated MCLR-induced brain injury, we firstly examined the reactive oxygen species (ROS) generation in the zebrafish brain.The results showed that co-exposure with nano-TiO2 could further increase ROS content compared with MCLR only groups. We also detected a significant change of lipid peroxidation products (MDA, malondialdehyde) content, antioxidant enzyme (SOD, superoxide dismutase) activity, and non-enzymatic antioxidant (GSH, glutathione) content in MCLR-co-nano-TiO2 groups. Transcriptional analysis indicated the expression of genes related to the antioxidant system was significantly altered in the zebrafish brain. Collectively, the observations in this study showed that the existence nano-TiO2 could exacerbate the damage of the zebrafish brain through the aggravation of MCLR-induced oxidative stress, ultimately leading to the abnormity of swimming behavior and social behavior. (C) 2019 Elsevier B.V. All rights reserved.

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