您好，欢迎访问湖北省农业科学院 机构知识库！
湖北省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Molecular mechanism of reproductive toxicity induced by beta-cypermethrin in zebrafish

文献类型： 外文期刊

作者： Lu, Juanli 1 ; Wu, Qin 2 ; Yang, Qing 3 ; Li, Guangyu 1 ; Wang, Ruiqi 1 ; Liu, Yingxin 1 ; Duan, Cunyu 1 ; Duan, Shiyun 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

2.Hubei Normal Univ, Hubei Key Lab Edible Wild Plants Conservat & Util, Cihu Rd, Huangshi 435002, Hubei, Peoples R China

3.Minist Water Resources & Chinese Acad Sci, Minist Water Resources, Inst Hydroecol, Key Lab Ecol Impacts Hydraul Projects & Restorat, Wuhan 430079, Peoples R China

4.Chinese Acad Chinese Sci, Wuhan 430079, Peoples R China

5.Hubei Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Wuhan 430064, Peoples R China

6.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Beta-cypermethrin; Zebrafish; Reproduction; HPG axis; Molecular mechanisms

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：3.228； 五年影响因子：3.289 ）

ISSN： 1532-0456

年卷期： 2021 年 239 卷

页码：

收录情况： SCI

摘要： Beta-cypermethrin, a type II synthetic pyrethroid insecticide, is widely used in pest control. Several studies have demonstrated that beta-cypermethrin can affect the reproductive system of mammals. However, there is still a scarcity of information about the reproductive toxicity to fish induced by beta-cypermethrin and its molecular mechanism. Therefore, this study was conducted to address this scientific question, in which the adult zebrafish were exposed to 0 (blank control), 0 (acetone solvent control), 0.1, 0.5, and 2.5 mu g/L of beta-cypermethrin for 21 days. A decrease in cumulative egg production of zebrafish was observed, indicating that beta-cypermethrin had a negative impact on reproductive capacity of zebrafish. Regarding the histomorphological analysis of gonads, the delay of gonadal development was observed after exposure for 21 days. In addition, significant changes in plasma 17 beta-estradiol (E2) and testosterone (T) were found in zebrafish. Further exploration showed that the transcription levels of hypothalamic-pituitary-gonadal (HPG) axis-related genes were remarkably changed, which corresponded well with the alterations of hormone levels. These results demonstrated that beta-cypermethrin might have an adverse effect on the reproduction system of zebrafish through delaying gonadal development, disturbing sex hormone secretion, and affecting HPG axis gene expression. This study suggests that beta-cypermethrin poses a potential threat to the reproduction of fish populations, and the toxicity assessment of beta-cypermethrin plays a vital role in the environmental risk assessment of pesticides.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：湖北省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台