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Titanium dioxide nanoparticles decreases bioconcentration of azoxystrobin in zebrafish larvae leading to the alleviation of cardiotoxicity

文献类型： 外文期刊

作者： Nie, Hongyan 1 ; Pan, Meiqi 1 ; Chen, Juan 2 ; Yang, Qing 3 ; Hung, Tien-Chieh 4 ; Xing, Dan 5 ; Peng, Maomin 6 ; Peng, Xitian 6 ; Li, Guangyu 1 ; Yan, Wei 6 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

2.Changsha Xinjia Bioengn Co Ltd, Changsha 410000, Hunan, Peoples R China

3.Chinese Acad Sci, Key Lab Ecol Impacts Hydraul Projects, Restorat Aquat Ecosyst Minist Water Resources, Wuhan 430079, Peoples R China

4.Univ Calif Davis, Dept Biol & Agr Engn, Davis, CA 95616 USA

5.Dadu River Hydropower Dev Co Ltd, Chengdu, Peoples R China

6.Hubei Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Hubei Key Lab Nutr Qual & Safety Agroprod, Wuhan 430064, Hubei, Peoples R China

7.Hubei Prov Engn Lab Pond Aquaculture, Wuhan 430070, Peoples R China

关键词： Titanium dioxide nanoparticles; Azoxystrobin; Cardiotoxicity; Mitochondrial dysfunction

期刊名称：CHEMOSPHERE （ 影响因子：8.943； 五年影响因子：8.52 ）

ISSN： 0045-6535

年卷期： 2022 年 307 卷

页码：

收录情况： SCI

摘要： Interactions between titanium dioxide nanoparticles (n-TiO2) and pollutants in the aquatic environment may alter the bioavailability of pollutants, and thus altering their toxicity and fate. In order to investigate the bio-concentration of azoxystrobin (AZ) and its mechanism of cardiotoxicity in the presence of n-TiO2, the experiment was divided into control, n-TiO2 (100 mu g/L), AZ (40, 200 and 1000 mu g/L) and AZ (40, 200, 1000 mu g/L) +n-TiO2 groups, and the zebrafish embryos were exposed to the exposure solution until 72 h post-fertilization. Results suggested the presence of n-TiO2 notably reduced the accumulation of AZ in larvae compared with exposure to AZ alone, thereby significantly decreasing AZ-induced cardiotoxicity, including heart rate changes, pericardium edema, venous thrombosis, increased sinus venosus and bulbus arteriosus distance and changes in cardiac -related gene expression. Further studies showed that AZ +n-TiO2 together restrained total-ATPase and Ca2+- ATPase activities, while the activity of Na+K+-ATPase increased at first and then decreased. Furthermore, there were significant changes in the expressions of oxidative phosphorylation and calcium channel-related genes, suggesting mitochondrial dysfunction may be the potential mechanism of cardiotoxicity induced by AZ and n-TiO2. This study supplies a new perspective for the joint action of AZ and environmental coexisting pollutants and provides a basis for ecological risk management of pesticides.

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