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Valine supplementation during late pregnancy in gilts increases colostral protein synthesis through stimulating mTOR signaling pathway in mammary cells

文献类型： 外文期刊

作者： Che, Long 1 ; Xu, Mengmeng 1 ; Gao, Kaiguo 3 ; Wang, Li 3 ; Yang, Xuefen 3 ; Wen, Xiaolu 3 ; Xiao, Hao 3 ; Jiang, Zongyon 1 ;

作者机构： 1.Minist Agr, Key Lab Anim Dis Resistance Nutr & Feed Sci, Chengdu, Sichuan, Peoples R China

2.Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China

3.State Key Lab Livestock & Poultry Breeding, Guangzhou, Guangdong, Peoples R China

4.Minist Agr, Key Lab Anim Nutr & Feed Sci South China, Guangzhou, Guangdong, Peoples R China

5.Guangdong Publ Lab Anim Breeding & Nutr, Guangzhou, Guangdong, Peoples R China

6.Guangdong Key Lab Anim Breeding & Nutr, Guangzhou, Guangdong, Peoples R China

7.Guangdong Acad Agr Sci, Inst Anim Sci, 1 Dafeng St,Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China

关键词： Valine; PMEC; mTOR; Lactation sows

期刊名称：AMINO ACIDS （ 影响因子：3.52； 五年影响因子：3.6 ）

ISSN： 0939-4451

年卷期： 2019 年 51 卷 10-12 期

页码：

收录情况： SCI

摘要： Mammary gland development during late pregnancy in sows is a major factor affecting the composition of colostrum and milk and the pre-weaning growth of piglets, while valine is essential for protein and nitrogen metabolism in mammary gland of sow. However, the effects of valine and its underlying mechanism on mammary gland development during late pregnancy are still unclear. Here, we hypothesized that dosage of dietary valine during late pregnancy will affect protein synthesis of colostrum in gilts. The results showed that supplementation of valine during late pregnancy significantly increased content of protein (P < 0.01), fat (P = 0.02) and solids-non-fat (P = 0.04) in colostrum. Our in vitro study also confirmed that valine supplementation increased protein synthesis and cell proliferation in porcine mammary epithelial cells (PMEC). Furthermore, these changes were associated with elevated phosphorylation levels of mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase (S6) and eukaryotic initiation factor 4E-binding protein-1 (4EBP1) in valine-supplemented cells, which could be effectively blocked by the antagonists of mTOR. These findings indicated that valine enhanced mammary gland development and protein synthesis in colostrum via the mTOR signaling pathway. These results, using an in vivo and in vitro model, helped to understand the beneficial effects of dietary valine supplementation on gilts.

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