文献类型： 外文期刊
作者： Fan, Baochao 1 ; Jiao, Dian 1 ; Zhang, Ruoxi 4 ; Zhou, Jinzhu 1 ; Guo, Rongli 1 ; Yu, Zhengyu 1 ; Shi, Danyi 1 ; Zhao, Yo 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Minist Agr, Key Lab Vet Biol Engn & Technol, Inst Vet Med, Nanjing, Jiangsu, Peoples R China
2.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Jiangsu Key Lab Zoonosis, Yangzhou, Jiangsu, Peoples R China
3.Minist Sci & Technol, State Key Lab Cultivat Base, Jiangsu Key Lab Food Qual & Safety, Nanjing, Jiangsu, Peoples R China
4.Hebei Prov Ctr Anim Dis Control & Prevent, Shijiazhuang, Hebei, Peoples R China
5.Hebei Normal Univ Sci & Technol, Coll Anim Sci & Technol, Qinhuangdao, Hebei, Peoples R China
6.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Jiangsu, Peoples R China
7.Nanjing Agr Univ, Coll Vet Med, Nanjing, Jiangsu, Peoples R China
关键词： China; porcine epidemic diarrhea virus; recombination; variant strains; virus origin
期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：5.005； 五年影响因子：4.622 ）
ISSN： 1865-1674
年卷期：
页码：
收录情况： SCI
摘要： From 2010, porcine epidemic diarrhea virus (PEDV) variants caused sequential outbreaks of disease in Asia and the United States. In this retrospective study, 49 complete spike (S) gene sequences were obtained from PEDV strains collected in China from 2014 to 2016. We observed that variant PEDV strains with novel insertions, deletions, and multiple S gene recombination types were present in China. In addition, mixed infections involving different variant strains were observed in some areas. Based on phylogenetic and recombination analyses, we determined that the newly emerged PEDV variants potentially originated via recombination between the earliest Chinese G1 genogroup strain, JS-2004-2 and earlier Korean pandemic strains. These findings provide important information for understanding ongoing PEDV outbreaks and suggest that novel variants make it more difficult to prevent PEDV infection.
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