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Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH-SY5Y cells

文献类型： 外文期刊

作者： Huang, Cui 1 ; Ma, Jing 1 ; Li, Bai-Xiang 1 ; Sun, Yan 1 ;

作者机构： 1.Harbin Med Univ, Sch Publ Hlth, Dept Toxicol, 157 Baojian Rd, Harbin 150081, Heilongjiang, Peoples R China

2.Heilongjiang Acad Agr Sci, Safety & Qual Inst Agr Prod, Harbin 150086, Heilongjiang, Peoples R China

关键词： Parkinson's disease; paraquat; maneb; wingless; SH-SY5Y

期刊名称：EXPERIMENTAL AND THERAPEUTIC MEDICINE （ 影响因子：2.447； 五年影响因子：2.263 ）

ISSN： 1792-0981

年卷期： 2019 年 18 卷 5 期

页码：

收录情况： SCI

摘要： Wingless (Wnt) signaling regulates the proliferation and differentiation of midbrain dopamine (DA) neurons. Paraquat (PQ) and maneb (MB) are environmental pollutants that can be used to model Parkinson's disease (PD) in rodents. A previous study demonstrated that developmental exposure to PQ and MB affects the expression of Wnt1, Wnt5a, nuclear receptor-related factor 1 (NURR1) and tyrosine hydroxylase (TH). However, how Wnt signaling regulates these developmental factors in vitro is yet to be determined. To explore this, SH-SY5Y cells were exposed to PQ and MB. The results of the current study indicated that exposure to PQ and MB decreased Wnt1, beta-catenin, NURR1 and TH levels and increased Wnt5a levels. Furthermore, Wnt1 silencing has the same effect as exposure to PQ and MB. Additionally, the neurotoxicity induced by PQ and MB is more severe in siWnt1-SH-SY5Y cells compared with normal SH-SY5Y cells. Therefore, Wnt1 may serve an important role in regulating developmental DA factors, and may be a candidate gene for PD diagnosis or gene therapy.

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