Discovery of lambda-lactam derivatives containing 1,3-benzodioxole unit as potential anti-phytopathogenic fungus agents
文献类型： 外文期刊
作者： Song, Di 1 ; Cao, Xiufang 1 ; Wang, Jingjing 1 ; Ke, Shaoyong 2 ;
作者机构： 1.Huazhong Agr Univ, Coll Sci, Wuhan 430070, Hubei, Peoples R China
2.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Hubei, Peoples R China
关键词： gamma-Lactam; 1,3-Benzodioxole; Diversity-oriented; Antifungal activities; Agricultural fungi
期刊名称：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS （ 影响因子：2.823； 五年影响因子：2.677 ）
ISSN： 0960-894X
年卷期： 2020 年 30 卷 2 期
页码：
收录情况： SCI
摘要： A series of gamma-lactam analogs containing 1,3-benzodioxole moiety were designed, and these derivatives were synthesized from the lead compound of lactam via a structural diversity-oriented synthesis, their structures were confirmed by (HNMR)-H-1, (CNMR)-C-13, ESI-MS spectrum. Their antifungal activities were evaluated against four serious and typically crop-threatening agricultural fungi, including Rhizoctonia solani, Alternaria tenuis Nees, Gloeosporium theae-sinensis, and Fusarium graminearum. Some of these derivatives exhibited activity against Alternaria tenuis Nees higher than that of commercial fungicides carbendazim, such as compounds 7a, 7b, and 7i, compared with the blank control, some of these derivatives showed good antifungal activities against Gloeosporium theae-sinensis and Fusarium graminearum. The systematic study provides evidences for further structural modification and application of lactam analogues as antifungal agents for agriculture.
- 相关文献
作者其他论文 更多>>
-
Discovery of structural diversity guided steroidal thiazolidin-4-one derivatives as potential cytotoxic agents targeting CDK1
作者：Yang, Fei;Min, Yong;Li, Kui;Yang, Ziwen;Wang, Kaimei;Gong, Yan;Liu, Manli;Ke, Shaoyong;Yang, Fei;Yang, Ziwen;Liu, Changli
关键词：Steroidal thiazolidin-4-ones; Structural diversity; Antiproliferative activity; Enzyme inhibitors; Molecular docking
-
A soybean cyst nematode suppresses microbial plant symbionts using a lipochitooligosaccharide-hydrolysing enzyme
作者：Chen, Wei;Wang, Di;Xiang, Wensheng;Yang, Qing;Chen, Wei;Yang, Qing;Ke, Shaoyong;Cao, Yangrong;Guo, Xiaoli
关键词：
-
Substituted pyrazole derivatives as potential fungicidal agents
作者：Huang, Daye;Liu, Fang;Wen, Shaohua;Wang, Yueying;Fang, Wei;Zhang, Zhigang;Ke, Shaoyong
关键词：Pyrazole carboxamide; Hydrazone; Plant disease; Fungicidal activity
-
Highly efficient construction of multi-substituted aminopyrazoles derivatives via iodine-mediated three-components reaction as potential anticancer agents
作者：Gao, Zilin;Liu, Manli;Shi, Liqiao;Zhang, Zhigang;Yang, Fei;Wang, Kaimei;Ke, Shaoyong;Gao, Zilin;Chen, Yu;Cao, Xiufang;Huang, Wenbo;Yang, Fei;Cao, Xiufang;Wang, Kaimei;Ke, Shaoyong
关键词：Aminipyrazole derivatives; three-component reaction; reaction mechanism; biological application; SARs; kinase inhibitor; molecular docking
-
Discovery of Novel Carboxamide Derivatives Containing Biphenyl Pharmacophore as Potential Fungicidal Agents Used for Resistance Management
作者：Ke, Shaoyong;Gao, Zilin;Zhang, Zhigang;Liu, Fang;Wen, Shaohua;Wang, Yueying;Huang, Daye;Gao, Zilin
关键词：biphenyl derivatives; synthesis; fungicidalactivity; Botrytis cinerea; resistantstrain; mode of action
-
Novel Steroidal[17,16-d]pyrimidines Derived from Epiandrosterone and Androsterone: Synthesis, Characterization and Configuration-Activity Relationships
作者：Yang, Fei;Yang, Ziwen;Yang, Fei;Liu, Fang;Min, Yong;Shi, Liqiao;Liu, Manli;Wang, Kaimei;Ke, Shaoyong;Gong, Yan;Yang, Ziwen
关键词：epiandrosterone; androsterone; steroidal[17; 16-d]pyrimidines; synthesis; bioactivity; molecular docking; SARs
-
N-Arylation of Amino Acid Esters via an I2-Mediated Metal-Free Multicomponent Benzannulation Strategy
作者：Shi, Liqiao;Wu, Hongqu;Ke, Shaoyong;Huang, Wenbo;Yang, Bing;Kuang, Buxiao;Rao, Xiaofeng;Rao, Xiaofeng;Liu, Changhui
关键词：
