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Synthesis and antibacterial activity of chalcone derivatives containing thioether triazole

文献类型： 外文期刊

作者： Chen, Ying 1 ; Li, Pu 1 ; Chen, Mei 1 ; He, Jun 1 ; Su, Shijun 1 ; He, Ming 1 ; Wang, Hua 2 ; Xue, Wei 1 ;

作者机构： 1.Guizhou Univ, Ctr Res & Dev Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Peoples R China

2.Hubei Acad Agr Sci, Inst Plant Protect & Soil Sci, Wuhan 430064, Peoples R China

期刊名称：JOURNAL OF HETEROCYCLIC CHEMISTRY （ 影响因子：2.193； 五年影响因子：1.645 ）

ISSN： 0022-152X

年卷期： 2020 年 57 卷 3 期

页码：

收录情况： SCI

摘要： The infection of Xanthomonas oryzae pv. Oryzae (Xoo), Ralstonia solanacearum (Rs), and Xanthomonas axonopodis pv. Citri (Xac) has become a major problem in agricultural production. In this study, a series of novel chalcone derivatives containing thioether triazoles were designed and synthesized. The structures of the novel compounds were systematically characterized via H-1-NMR, C-13-NMR, and HRMS. Moreover, the antibacterial activity results showed that E-10, E-11, E-15, and E-16 have adequate antibacterial activities against Xoo, Rs, and Xac. Among the different compounds, E-15 exhibited remarkable inhibitory effect against Xac with an EC50 of 9.1 mu g.mL(-1), which was better than that of commercial agent bismerthiazol (54.9 mu g.mL(-1)). In addition, the possible antibacterial mechanism of the target compound E-15 against Xac was studied via scanning electron microscopy (SEM).

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