Novel insights into Dhh signaling in antler chondrocyte proliferation and differentiation: Involvement of Foxa
文献类型： 外文期刊
作者： Ma, Li 1 ; Duan, Cui-Cui 2 ; Yang, Zhan-Qing 1 ; Ding, Jun-Li 1 ; Liu, Shu 1 ; Yue, Zhan-Peng 1 ; Guo, Bin 1 ;
作者机构： 1.Jilin Univ, Coll Vet Med, Changchun 130062, Peoples R China
2.Jilin Acad Agr Sci, Inst Agrofood Technol, Changchun, Peoples R China
关键词： antler; chondrocyte; Dhh signaling; Foxa; proliferation and differentiation
期刊名称：JOURNAL OF CELLULAR PHYSIOLOGY （ 影响因子：6.384； 五年影响因子：5.987 ）
ISSN： 0021-9541
年卷期：
页码：
收录情况： SCI
摘要： The desert hedgehog (Dhh) is crucial for spermatogenesis and Leydig cell differentiation, but little is known regarding its physiological function in cartilage. In this study, Dhh mRNA was abundant in antler chondrocytes, where it advanced cell proliferation concomitant with accelerated transition from the G1 to the S phase and induced elevation of the hypertrophic chondrocyte markers, Col X and Runx2. Silencing of Ptch1 resulted in appreciable Smo accumulation and enhanced rDhh stimulation of Smo, whose impediment by cyclopamine obscured the proliferative function of Dhh and alleviated its guidance of chondrocyte differentiation. Further analysis evidenced the noteworthy positive action of Smo in the bridging between Dhh and Gli transcription factors. Obstruction of Gli1 by GANT58 caused the failed stimulation of Col X and Runx2 by rDhh. Analogously, siRNA against Gli1-3 hindered chondrocyte differentiation in the context of rDhh. Simultaneously, Gli transcription factors mediated the regulation of Dhh on Foxa1, Foxa2, and Foxa3, whose knockdown impaired chondrocyte differentiation. Attenuation of Foxa antagonized the augmentation of Col X and Runx2 generated by rDhh. Collectively, Dhh signaling through its target Foxa appears to induce antler chondrocyte proliferation and differentiation.
- 相关文献
作者其他论文 更多>>
-
Enhancing the carbon content of coal gangue for composting through sludge amendment: A feasibility study
作者：Luo, Chi;Li, Shaohua;Ren, Pengyu;Yan, Fan;Wang, Lu;Guo, Bin;Zhao, Yimo;Yang, Yue;Gao, Pengcheng;Ji, Puhui;Sun, Jian
关键词：High-carbon coal gangue; Sludge; Cocomposting; Maturity
-
Material flow analysis of heavy metals in large-scale cattle farms and ecological risk assessment of cattle manure application to fields
作者：Guo, Bin;Ren, Pengyu;Wang, Lu;Li, Shaohua;Luo, Chi;Zhao, Yimo;Ji, Puhui;Zhao, Hanghang;Sun, Jian
关键词：Large-scale farms; Forage; Cattle manure; Material flow analysis; Heavy metals; Ecological risks
-
Malic enzyme 1 is important for uterine decidualization in response to progesterone/cAMP/PKA/HB-EGF pathway
作者：Yu, Hai-Fan;Yang, Zhan-Qing;Wang, Yu-Si;Yue, Zhan-Peng;Guo, Bin;Duan, Cui-Cui
关键词：decidualization; Me1; mitochondrial function; HB-EGF; progesterone-cAMP-PKA pathway; uterus
-
Activity adaptability of a DhHP-6 peroxidase-mimic in wide pH and temperature ranges and solvent media
作者：Yan, Jiaqing;Li, Zhengqiang;Wang, Zhi;Yan, Jiaqing;Liu, Min;Sun, Xiaoli;Huang, Xuri;Ma, Li;Zhao, Zijian;Yuan, Long
关键词：
-
HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage
作者：Yu, Hai-Fan;Yang, Zhan-Qing;Wang, Yu-Si;Yue, Zhan-Peng;Guo, Bin;Duan, Cui-Cui
关键词：
-
Crosstalk between Activin A and Shh signaling contributes to the proliferation and differentiation of antler chondrocytes
作者：Ma, Li;Yang, Zhan-Qing;Ding, Jun-Li;Liu, Shu;Yue, Zhan-Peng;Guo, Bin;Duan, Cui-Cui
关键词：Activin A; Shh and Notch signaling; Foxa; Proliferation and differentiation; Antler chondrocyte
-
WNT4 acts downstream of BMP2 to mediate the regulation of ATRA signaling on RUNX1 expression: Implications for terminal differentiation of antler chondrocytes
作者：Zhang, Hong-Liang;Yang, Zhan-Qing;Geng, Shuang;Wang, Kai;Yu, Hai-Fan;Yue, Zhan-Peng;Guo, Bin;Duan, Cui-Cui
关键词：antler chondrocyte terminal differentiation;ATRA signaling;BMP2;RUNX1;WNT4
