Dual-target electrochemical aptasensor based on co-reduced molybdenum disulfide and Au NPs (rMoS(2)-Au) for multiplex detection of mycotoxins
文献类型： 外文期刊
作者： Han, Zheng 1 ; Tang, Zhanmin 1 ; Jiang, Keqiu 1 ; Huang, Qingwen 1 ; Meng, Jiajia 1 ; Nie, Dongxia 1 ; Zhao, Zhihui 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Shanghai Key Lab Protected Hort Technol, Lab Qual & Safety Risk Assessment Agroprod Shangh, Minist Agr,Inst Agrofood Stand & Testing Technol, Shanghai 201403, Peoples R China
2.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
关键词： Co-reduced molybdenum disulfide and Au NPs (rMoS(2)-Au); Electrochemical aptasensor; Zearalenone; Fumonisin B1
期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：10.618； 五年影响因子：9.323 ）
ISSN： 0956-5663
年卷期： 2020 年 150 卷
页码：
收录情况： SCI
摘要： Multiple mycotoxin contamination has posed health risks in the area of food safety. In this study, co-reduced molybdenum disulfide and gold nanoparticles (rMoS(2)-Au) were designed and used for the first time as an efficient platform endowing electrochemical electrodes with superior electron transfer rates, large surface areas and strong abilities to firmly couple with large amounts of different aptamers. After further modification with thionine (Thi) and 6-(Ferrocenyl) hexanethiol (FC6S), a platform enabling sensitive, selective and simultaneous determination of two important mycotoxins, zearalenone (ZEN) and fumonisin B1 (FB1), was achieved. The established aptasensor showed excellent linear relationships (R-2 > 0.99) when ZEN and FB1 concentrations were in the range of 1 x 10(-3) -10 ng mL(-1) and 1 x 10(-3) -1 x 10(2) ng mL(-1), respectively. High sensitivity of ZEN and FB1 with a limit of detection as low as 5 x 10(-4) ng mL(-1) was obtained with excellent selectivity and stability. The effectiveness of the aptasensor was verified in real maize samples, and satisfactory recoveries were attained. The established platform could be easily expanded to other aptamer-based multiplex screening protocols in biochemical research and clinical diagnosis.
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