A rare gain of function mutation in a wheat tandem kinase confers resistance to powdery mildew
文献类型： 外文期刊
作者： Lu, Ping 1 ; Guo, Li 2 ; Wang, Zhenzhong 2 ; Li, Beibei 1 ; Li, Jing 4 ; Li, Yahui 5 ; Qiu, Dan 5 ; Shi, Wenqi 6 ; Yang, Lij 1 ;
作者机构： 1.Chinese Acad Sci, Innovat Acad Seed Design, Inst Genet & Dev Biol, State Key Lab Plant Cell & Chromosome Engn, Beijing 100101, Peoples R China
2.China Agr Univ, Coll Agron & Biotechnol, Beijing 100193, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Beijing Agr Univ, Plant Sci & Technol Coll, Beijing 102206, Peoples R China
5.Chinese Acad Agr Sci, Inst Crop Sci, Natl Engn Lab Crop Mol Breeding, Beijing 100081, Peoples R China
6.Hubei Acad Agr Sci, Inst Plant Protect & Soil Sci, Wuhan 430064, Peoples R China
7.China Agr Univ, Coll Hort, Beijing 100193, Peoples R China
8.Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA
9.ARS, USDA, Western Reg Res Ctr, Albany, CA 94710 USA
期刊名称：NATURE COMMUNICATIONS （ 2020影响因子：14.919； 五年影响因子：15.805 ）
ISSN： 2041-1723
年卷期： 2020 年 11 卷 1 期
收录情况： SCI
摘要： Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is one of the most destructive diseases that pose a great threat to wheat production. Wheat landraces represent a rich source of powdery mildew resistance. Here, we report the map-based cloning of powdery mildew resistance gene Pm24 from Chinese wheat landrace Hulutou. It encodes a tandem kinase protein (TKP) with putative kinase-pseudokinase domains, designated WHEAT TANDEM KINASE 3 (WTK3). The resistance function of Pm24 was validated by transgenic assay, independent mutants, and allelic association analyses. Haplotype analysis revealed that a rare 6-bp natural deletion of lysine-glycine codons, endemic to wheat landraces of Shaanxi Province, China, in the kinase I domain (Kin I) of WTK3 is critical for the resistance function. Transgenic assay of WTK3 chimeric variants revealed that only the specific two amino acid deletion, rather than any of the single or more amino acid deletions, in the Kin I of WTK3 is responsible for gaining the resistance function of WTK3 against the Bgt fungus.
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