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Ochratoxin A in human blood plasma samples from apparently healthy volunteers in Nanjing, China

文献类型： 外文期刊

作者： Fan, Kai 1 ; Cheng, Xi 1 ; Guo, Wenbo 2 ; Liu, Xing 2 ; Zhang, Zhiqi 2 ; Yao, Qi 3 ; Nie, Dongxie 2 ; Yao, Bing 1 ; Han, Zhe 1 ;

作者机构： 1.Nanjing Univ, Nanjing Jinling Hosp, Reprod Med Ctr, Sch Med, Nanjing 210002, Jiangsu, Peoples R China

2.Shanghai Acad Agr Sci, Inst Agrofood Stand & Testing Technol, Shanghai Key Lab Protected Hort Technol, Shanghai 201403, Peoples R China

3.Nanjing Univ Tradit Chinese Med, Sch Med & Life Sci, Dept Pathol & Pathophysiol, Nanjing 210023, Jiangsu, Peoples R China

关键词： Ochratoxin A; Exposure assessment; Plasma; Biomarker

期刊名称：MYCOTOXIN RESEARCH （ 影响因子：3.833； 五年影响因子：4.558 ）

ISSN： 0178-7888

年卷期：

页码：

收录情况： SCI

摘要： This study was conducted to investigate the exposure to ochratoxin A (OTA) of populations living in Nanjing, China. Plasma samples were collected from 147 healthy adults (age 18-63 years) and analyzed for OTA by a reliable and sensitive ultra-high-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method (limit of detection 0.04 ng/mL). After enzymatic hydrolysis by beta-glucuronidase/arylsulfatase, OTA was detected in 80.9% plasma samples with mean concentration of 0.26 +/- 0.59 ng/mL (range 0.04-6.59 ng/mL). The estimated daily intakes of OTA based on plasma concentrations (mean 0.51 ng/kg bw/day, max 12.99 ng/kg bw/day) were lower than the tolerable daily intake published by European Food Safety Authority (EFSA) or Joint FAO/WHO Expert Committee on Food Additives (JFECFA) indicative of rare risks related to the OTA exposure in the investigated area. This study provides a valuable insight on human exposure to OTA in China. Further studies in children and elder people and in adult cohorts from other regions are recommended.

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