Effects of 27 natural products on drug metabolism genes in channel catfish (Ictalurus punctatus) cell line
文献类型： 外文期刊
作者： Wang, Zhenyue 1 ; Liu, Yongtao 2 ; Ai, Xiaohui 2 ; Zhong, Liqiao 2 ; Han, Gang 3 ; Song, Jinlong 3 ; Yang, Qiuhong 2 ; Do 1 ;
作者机构： 1.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai, Peoples R China
2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Control Qual & Safety Aquat Prod, Beijing, Peoples R China
4.Hubei Prov Engn & Technol Res Ctr Aquat Prod Qual, Wuhan, Peoples R China
5.Chinese Acad Fishery Sci, Aquat Prod Qual & Stand Res Ctr, Beijing, Peoples R China
关键词： Natural products; pregnane X receptor; cytochrome P450; in vitro; multi-drug resistance 1
期刊名称：XENOBIOTICA （ 影响因子：1.908； 五年影响因子：1.917 ）
ISSN： 0049-8254
年卷期：
页码：
收录情况： SCI
摘要： Pregnane X receptor (PXR) as a ligand dependent transcription factor, is capable of regulating gene expression of cytochromes P450 and transporters involved in xenobiotic/drug metabolism and elimination. Due to the species differences in the regulatory specificity of PXR, gene regulation should not be extrapolated from mammal to fish without research data. The aim of present study was to investigate the effect of 27 natural products on PXR, CYP3A30 and MDR1 genes in channel catfish (Ietalurus punetaus) kidney cells (CC-K). The results showed that bisdemethoxycurcumin, glycyrrhetnic acid, rotenone, artemisinin, dihydroartemisinin, ligustilide and matrine strongly induced the mRNA levels of PXR. Additionally, the up-regulation of CYP3A30 gene ran parallel with PXR gene after the treatment of demethoxycurcumin, glycyrrhetnic acid, artemisinin, matrine, baicalein, schisantherin A, ligustilide, and dihydroartemisinin. Moreover, we found that natural products schisandrin A, schisandrin B, schisandrol A, and schisandrol B significantly up-regulated the mRNA level of MDR1 gene. Our work with a view to provide experimental data support for further research, which will make for the rational application of natural products in channel catfish, such as to avoid adverse herb-drug interactions or accelerating the residue elimination of chemical medicine.
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