Individual and combined cytotoxic effects of T-2 toxin and its four metabolites on porcine Leydig cells
文献类型： 外文期刊
作者： Ling, Aru 1 ; Sun, Lingwei 3 ; Guo, Wenbo 2 ; Sun, Shiyao 1 ; Yang, Junhua 2 ; Zhao, Zhihui 2 ;
作者机构： 1.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
2.Shanghai Acad Agr Sci, Inst Agrifood Stand & Testing Technol, Shanghai 201403, Peoples R China
3.Shanghai Acad Agr Sci, Anim Husb & Vet Res Inst, Shanghai 201106, Peoples R China
关键词： T-2 toxin and metabolites; Cytotoxicity; Combination index; Porcine Leydig cells
期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）
ISSN： 0278-6915
年卷期： 2020 年 139 卷
页码：
收录情况： SCI
摘要： T-2 toxin, one of the most toxic mycotoxins, is commonly presented along with its metabolites, HT-2 toxin, neosolaniol (NEO), T-2 triol, and T-2 tetraol in foodstuff and feed. The aim of this study was to evaluate the cytotoxic effects of T-2 toxin alone and in combination with its metabolites on porcine Leydig cells. Based on the determination of cell viability with CCK-8, toxicological interactions were investigated using Combination Index method. The cytotoxic potency of five tested mycotoxins individual and their mixtures all showed with a dosedependent manner. In view of IC50 values, the decreasing cytotoxicity of mycotoxins was ranking: T-2 toxin > HT-2 toxin > T-2 triol > NEO > T-2 tetraol. Combinations of T-2+HT-2, T-2+NEO, and HT-2+NEO displayed synergism at low doses but antagonism at high doses, while the ternary combination of T2+HT-2+NEO revealed adverse situation from antagonism to synergism. All binary and ternary combinations of T-2 toxin, T-2 triol, and T-2 tetraol exhibited antagonistic interactions. Our results suggest that the co-occurrence of T-2 toxin and its metabolites might pose a slight threat to reproductive health due to antagonistic interactions. However, the synergy observed should be not ignored especially at low doses of mycotoxins cooccurrence in the diet.
- 相关文献
作者其他论文 更多>>
-
Combined Toxicity Assessment of Deoxynivalenol and Pb2+ on HK-2 Cells Involved in Excessive ROS-Induced Ferroptosis
作者：Zhu, Zuoyin;Wang, Jie;Cheng, Haisheng;Zhou, Xinli;Zhu, Zuoyin;Wang, Jie;Cheng, Haisheng;Zhao, Hanke;Liu, Chengbin;Yang, Junhua
关键词：ferroptosis; combined toxicity; mycotoxins; heavy metals
-
Isoglycyrrhizin supplementation of frozen goat semen-extender improves post-thaw sperm quality and in vitro fertilization rates
作者：Liu, Fuqin;Sun, Lingwei;Xu, Jiehuan;He, Mengqian;Wu, Caifeng;Gao, Jun;Dai, Jianjun;Liu, Fuqin;Sun, Lingwei;Xu, Jiehuan;He, Mengqian;Wu, Caifeng;Gao, Jun;Dai, Jianjun;Shen, Haoxing;Zhu, Huibin;Luo, Feng
关键词：Shanghai chongming white goat; Semen cryopreservation; Isoglycyrrhizin (ISL); Antioxidant; Oxidative stress; In vitro fertilization
-
Occurrence of Co-Contamination and Interaction of Multi-Mycotoxins in Dairy Cow Feed in China
作者：Zhu, Zuoyin;Cheng, Haisheng;Wang, Jie;Zhou, Xinli;Zhu, Zuoyin;Cheng, Haisheng;Wang, Jie;Wang, Jianhua;Yang, Junhua;Ma, Junmei;Wang, Hongyang
关键词：feed; mycotoxin; co-contamination; correlation; interaction
-
Enhanced Electrochemical and Photochemical Sensors for In Vivo Biological Monitoring Based on Carbon Nanomaterials
作者：Huang, Qingwen;Lin, Xialin;Nie, Dongxia;Wang, Jie;Fan, Kai;Zhao, Zhihui;Han, Zheng;Lin, Xialin;Zhao, Zhihui
关键词：carbon nanomaterials; electrochemical sensors; in vivo detection; photochemical sensor
-
Inhibition Effects of Infrared Radiation Prior to Cold Storage Against Alternaria alternata on Yellow Peach (Amygdalus persica)
作者：Liu, Longxiao;Li, Zhizhong;Liu, Longxiao;Fan, Kai;Huang, Qingwen;Wang, Xinyi;Nie, Dongxia;Han, Zheng;Zhao, Zhihui
关键词：
Alternaria alternata ;Alternaria toxins; infrared radiation; yellow peach; inhibitory effect -
Integrated Cytotoxicity and Metabolomics Analysis Reveals Cell-Type-Specific Responses to Co-Exposure of T-2 and HT-2 Toxins
作者：He, Weihua;Wang, Qinggong;Zhai, Xiaohu;Zhu, Zuoyin;Xu, Jingru;Huang, Chengbao;Wang, Jianhua;Yang, Junhua
关键词：T-2 toxin; HT-2 toxin; porcine cells; metabolic pathways; biomarkers; combined toxicity
-
A host-guest recognition electrochemical sensor based on MXene/COF heterocomposite bound to β-cyclodextrin for the direct detection of zearalenone in cereals
作者：Fei, Qianqian;Bian, Ming;Han, Zheng;Fei, Qianqian;Huang, Qingwen;Nie, Dongxia;Fan, Kai;Wang, Xinyi;Zhao, Zhihui;Han, Zheng
关键词：Host-guest recognition; Label-free electrochemical sensors; Zearalenone; beta-Cyclodextrin; Covalent organic framework
