Intestinal metabolomics of juvenile lenok (Brachymystax lenok) in response to heat stress
文献类型： 外文期刊
作者： Chen, Yan 1 ; Liu, Yang 2 ; Bai, Yucen 3 ; Xu, Shaogang 1 ; Yang, Xiaofei 1 ; Cheng, Bo 4 ;
作者机构： 1.Beijing Acad Agr & Forestry Sci, Fisheries Sci Inst, Beijing Key Lab Fishery Biotechnol, Beijing 100097, Peoples R China
2.Qinghai Univ, Coll Ecoenvironm Engn, Xining 810016, Peoples R China
3.China Rural Technol Dev Ctr, 54 Sanlihe Rd, Beijing 100045, Peoples R China
4.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, Key Lab Aquat Prod Proc, Zhanjiang, Peoples R China
关键词： Heat stress; Intestinal; Metabolomics
期刊名称：FISH PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：3.014； 五年影响因子：3.187 ）
ISSN： 0920-1742
年卷期： 2022 年 48 卷 5 期
页码：
收录情况： SCI
摘要： Changes in the metabolic profile within the intestine of lenok (Brachymystax lenok) when challenged to acute and lethal heat stress (HS) are studied using no-target HPLC-MS/MS metabonomic analysis. A total of 51 differentially expressed metabolites (VIP > 1, P < 0.05) were identified in response to HS, and 34 occurred in the positive ion mode and 17 in negative ion mode, respectively. After heat stress, changes in metabolites related to glycolysis (i.e., alpha-D-glucose, stachyose, and L-lactate) were identified. The metabolites (acetyl carnitine, palmitoylcarnitine, carnitine, and erucic acid) related to fatty acid beta-oxidation accumulated significantly, and many amino acids (L-tryptophan, D-proline, L-leucine, L-phenylalanine, L-aspartate, L-tyrosine, L-methionine, L-histidine, and L-glutamine) were significantly decreased in HS-treated lenok. The mitochondrial beta-oxidation pathway might be inhibited, while severe heat stress might activate the anaerobic glycolysis and catabolism of amino acid for energy expenditure. Oxidative damage in HS-treated lenok was indicated by the decreased glycerophospholipid metabolites (i.e., glycerophosphocholine, 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine, 1-palmitoyl-sn-glycero-3-phosphocholine, 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine, and 1, 2-dioleoyl-sn-glycero-3-phosphatidylcholine) and the increased oxylipin production (12-HETE and 9R, 10S-EpOME). The minor oxidative pathways (omega-oxidation and peroxisomal beta-oxidation) were likely to be induced in HS-treated lenok.
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