Simultaneous determination of enantiomer residues of metalaxyl and its metabolite metalaxyl acid in animal muscle tissues by chiral liquid chromatography-tandem mass spectrometry
文献类型： 外文期刊
作者： Zhou, Hao 1 ; Shan, Qi 1 ; He, Limin 2 ; Zhang, Meiyu 3 ; Zhao, Cheng 1 ; Zheng, Guangming 1 ; Li, Lichun 1 ; Xu, Feng 4 ; Ma, Lisha 1 ; Yin, Yi 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, Pearl River Fisheries Res Inst, Key Lab Prevent & Control Aquat Invas Alien Specie, Guangzhou 510380, Peoples R China
2.South China Agr Univ, Coll Vet Med, Inspection & Testing Ctr Domest Anim Prod Guangzho, Qual Supervis,Minist Agr & Rural Affairs, Guangzhou 510642, Peoples R China
3.Guangdong Polytech Sci & Trade, Coll Anim Sci & Technol, Guangzhou 510640, Peoples R China
4.Chongqing Fisheries Tech Extens Ctr, Chongqing 400000, Peoples R China
关键词： Metalaxyl; Metabolite residue; Solid phase extraction; Chiral LC-MS/MS; Muscle tissues; Stereoselective analysis
期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）
ISSN： 0308-8146
年卷期： 2024 年 435 卷
页码：
收录情况： SCI
摘要： The toxicity of the two enantiomers of metalaxyl is significantly different and, for food safety concerns, stereoselective analysis of its residues is extremely important in animal muscle tissues. Herein, a simple, sensitive and reproducible method for the simultaneous stereoselective analysis of metalaxyl and its metabolite metalaxyl acid in animal-derived foods has been established based on mixed-mode anion exchange solid phase extraction and chiral liquid chromatography-tandem mass spectrometry. Under the optimized separation and sample pretreatment conditions, good linearity (r > 0.99) was obtained for four target analytes in four animal muscle tissues including bovine, chicken, swine and fish. Mean recoveries of all enantiomers in muscle tissue samples were 89.5-110.3 % with relative standard deviations below 12.4 %. The limits of quantification of the analytes were 0.3-1.0 mu g/kg. The proposed method provides an effective means to monitor the enantiomer residues in real samples whether using highly active R-metalaxyl or racemic mixture drugs.
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