Selective probes targeting c-MYC Pu22 G-quadruplex and their application in live mice imaging
文献类型： 外文期刊
作者： Yu, Zhuo 1 ; Huang, Wenbo 1 ; Shi, Liqiao 1 ; Ke, Shaoyong 1 ; Xu, Shengzhen 2 ;
作者机构： 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China
2.Huazhong Agr Univ, Coll Sci, Wuhan 430070, Peoples R China
关键词： Benthiazole; Conjugated system; Chemosensor; G-quadruplex DNA; In vivo imaging
期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：8.455； 五年影响因子：5.935 ）
ISSN： 1001-8417
年卷期： 2022 年 33 卷 3 期
页码：
收录情况： SCI
摘要： Several probes containing benzothiazole-guided conjugated systems (BGCS) were designed and synthesized, and two molecules (BGCS5 and BGCS6) of which were discovered as selective probes targeting c-MYC Pu22 G-quadruplex DNA. The fluorescence intensity of BGCS5 and BGCS6 in the presence of c-MYC Pu22 far exceeds that of the typical G4 probe TO1. Especially, the fluorescence of BGCS6 increased almost 193-fold in the presence of c-MYC Pu22 G4 compared to that alone in aqueous buffer condition with almost no fluorescence and 10-30 folds than those in the presence of other DNAs, which will be useful tools for disease detection in mammals. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
- 相关文献
作者其他论文 更多>>
-
Synthesis and Evaluation of Antifungal Activity of Novel Potent SDHI Fungicides Featuring a Conjugated Alkyne Structural Motif
作者：Bao, Longzhu;Zhou, Zifei;Yan, Xiaolong;Xu, Weilong;Li, Jun;Zhai, Qianqian;Teng, Huailong;Bao, Longzhu;Ke, Shaoyong;Chen, Yu
关键词：conjugated alkyne; succinate dehydrogenase; fungicides; enzyme activity; molecular docking
-
Natural Furan-Carboxylic Acid (HHCA) and Its Derivatives: Synthesis, Characterization, Bioevaluation, and Structure-Activity Relationships as Potential Fungicidal Agents
作者：Guo, Lirong;Wang, Hexiang;Zheng, Fuqiang;Liu, Fang;Zhang, Zhigang;Wang, Kaimei;Bao, Longzhu;Ke, Shaoyong;Guo, Lirong;Wang, Hexiang;Xu, Shiyu;Cao, Xiufang;Zheng, Fuqiang;Huang, Wenbo
关键词：natural product; HHCA; structural diversity; antifungal activity; SARs
-
In vitro inhibitory activity of indole alkaloid derivatives against porcine epidemic diarrhea virus
作者：Jian, Yaoying;Dong, Siqi;Zhang, Qianyi;Pan, Jiali;Ding, Zhen;Wu, Huansheng;Chen, Zheng;Hu, Ruiming;Ke, Shaoyong
关键词：
-
Natural pyrrolo[1,2-a]quinazolinone derivatives: Design, synthesis, characterization, and bio-evaluation as novel antiviral agents
作者：Wei, Yanhong;Zheng, Fuqiang;Chen, Wenxuan;Li, Ying;Alateng, W.;Su, Jianglong;Kong, Mengmeng;Zheng, Fuqiang;Guo, Lirong;Wang, Hexiang;Bao, Longzhu;Wu, Zhaoyuan;Ke, Shaoyong;Guo, Lirong;Wang, Hexiang
关键词：Natural product; Pyrrolo[1; a ]quinazolinone derivatives; Antiviral agents; EV71; CVB3
-
Peptidomimetics based on natural cinnamic acid scaffold: Synthesis, bio-evaluation and structure-activity relationships
作者：Guo, Lirong;Wang, Hexiang;Liu, Fang;Bao, Longzhu;Wu, Zhaoyuan;Ye, Ting;Zhang, Yani;Wang, Yueying;Fang, Wei;Ke, Shaoyong;Guo, Lirong;Wang, Hexiang;Cao, Xiufang;Duan, Liping;Duan, Liping;Duan, Liping;Duan, Liping
关键词：Natural product; Peptidomimetics; Cinnamic acid; Conjugates; Biological activity; SARs
-
A soybean cyst nematode suppresses microbial plant symbionts using a lipochitooligosaccharide-hydrolysing enzyme
作者：Chen, Wei;Wang, Di;Xiang, Wensheng;Yang, Qing;Chen, Wei;Yang, Qing;Ke, Shaoyong;Cao, Yangrong;Guo, Xiaoli
关键词：
-
Substituted pyrazole derivatives as potential fungicidal agents
作者：Huang, Daye;Liu, Fang;Wen, Shaohua;Wang, Yueying;Fang, Wei;Zhang, Zhigang;Ke, Shaoyong
关键词：Pyrazole carboxamide; Hydrazone; Plant disease; Fungicidal activity
