Reduction of ROS-HIF1 alpha-driven glycolysis by taurine alleviates Streptococcus uberis infection
文献类型： 外文期刊
作者： Lan, Riguo 1 ; Zhou, Yuanyuan 1 ; Wang, Zhenglei 1 ; Fu, Shaodong 1 ; Gao, Yabing 1 ; Gao, Xing 1 ; Zhang, Jinqiu 2 ; Han, Xiangan 3 ; Phouthapane, Vanhnaseng 4 ; Xu, Yuanyuan 1 ; Miao, Jinfeng 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Key Lab Anim Physiol & Biochem, Nanjing 210095, Peoples R China
2.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Vaccine Engn & Technol China, Nanjing 210014, Peoples R China
3.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
4.Minist Agr & Forestry, Dept Livestock & Fisheries, Viangchan, Laos
期刊名称：FOOD & FUNCTION （ 影响因子：6.317； 五年影响因子：6.375 ）
ISSN： 2042-6496
年卷期： 2022 年 13 卷 4 期
页码：
收录情况： SCI
摘要： Antibiotic-resistant strains of Streptococcus uberis (S. uberis) frequently cause clinical mastitis in dairy cows resulting in enormous economic losses. The regulation of immunometabolism is a promising strategy for controlling this bacterial infection. To investigate whether taurine alleviates S. uberis infection by the regulation of host glycolysis via HIF1 alpha, the murine mammary epithelial cell line (EpH4-Ev) and C57BL/6J mice were challenged with S. uberis. Our data indicate that HIF1 alpha-driven glycolysis promotes inflammation and damage in response to the S. uberis challenge. The activation of HIF1 alpha is dependent on mTOR-mediated ROS production. These results were confirmed in vivo. Taurine, an intracellular metabolite present in most animal tissues, has been shown to effectively modulate HIF1 alpha-triggered metabolic reprogramming and contributes to a reduction of inflammation, which reduces mammary tissue damage and prevents mammary gland dysfunction in S. uberis-induced mastitis. These data provide a novel putative prophylactic and therapeutic strategy for amelioration of dairy cow mastitis and bacterial inflammation.
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