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The Effect of Polyphenol Extract from Rosa Roxburghii Fruit on Plasma Metabolome and Gut Microbiota in Type 2 Diabetic Mice

文献类型： 外文期刊

作者： Wang, Hui 1 ; Chen, Zhaojun 2 ; Wang, Mei 2 ; Long, Mingxiu 3 ; Ren, Tingyuan 4 ; Chen, Chao 4 ; Dai, Xiaotong 4 ; Yang, Sheng 4 ; Tan, Shuming 1 ;

作者机构： 1.Guizhou Univ, Key Lab Plant Resource Conservat & Germplasm Inno, Minist Educ, Coll Life Sci,Inst Agro Bioengn, Guiyang 550025, Peoples R China

2.Guizhou Acad Agr Sci, Inst Biotechnol, Guiyang 550025, Peoples R China

3.Guizhou Acad Agr Sci, Guizhou Res Inst Modern Agr Dev, Guiyang 550025, Peoples R China

4.Guizhou Univ, Coll Liquor & Food Engn, Key Lab Agr & Anim Prod Storage & Proc Guizhou Pr, Guiyang 550025, Peoples R China

关键词： Rosa roxburghii fruit; type 2 diabetes; plasma metabolome; gut microbiota

期刊名称：FOODS （ 影响因子：5.561； 五年影响因子：5.94 ）

ISSN：

年卷期： 2022 年 11 卷 12 期

页码：

收录情况： SCI

摘要： Rosa roxburghii fruit is an underutilized functional food abundant in polyphenols. Polyphenols have been proved to have antidiabetic effects. This study investigates the effects of Rosa roxburghii fruit polyphenols extract (RPE) on plasma metabolites and gut microbiota composition in streptozotocin (STZ)- and high-fat diet- induced type 2 diabetes using metabolomics and 16S rRNA gene sequencing. The induced diabetic mice were fed with 400 mg/kg body weight RPE for 8 weeks. RPE demonstrated hypoglycemic, hypolipidemic, and anti-inflammatory effects. Colonic oxidative stress biomarkers were also lowered by RPE. Besides, RPE decreased plasma ceramides and tyrosine levels and increased carnitine and phosphatidylinositols levels, indicating improved insulin resistance, lipid metabolism, and immune response. Furthermore, RPE decreased abundances of Lachnospiraceae and Rikenellaceae and increased abundances of Erysipelotrichaceae and Faecalibaculum. Metabolic function prediction of the gut microbiota by PICRUSt demonstrated that RPE downregulated the phosphotransferase system. Taken together, these findings demonstrated that RPE has the potential to prevent type 2 diabetes by regulating the plasma metabolites and gut microbes.

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