文献类型： 外文期刊
作者： Ma, Guang-Wei 1 ; Wang, Shou-Zhi 4 ; Wang, Ning 4 ; Li, Hui 4 ; Yang, Hua 3 ;
作者机构： 1.Hainan Normal Univ, Minist Educ, Key Lab Ecol Trop Isl, Haikou 571158, Hainan, Peoples R China
2.Hainan Normal Univ, Coll Life Sci, Key Lab Trop Anim & Plant Ecol Hainan Prov, Haikou 571158, Hainan, Peoples R China
3.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China
4.Northeast Agr Univ, Minist Agr & Rural Affairs, Key Lab Chicken Genet & Breeding, Harbin 150030, Peoples R China
5.Northeast Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod, Educ Dept Heilongjiang Prov, Harbin 150030, Peoples R China
关键词： SHCBP1; Tissue expression; SNP; Wool crimp
期刊名称：BIOCHEMICAL GENETICS （ 影响因子：2.22； 五年影响因子：2.077 ）
ISSN： 0006-2928
年卷期：
页码：
收录情况： SCI
摘要： SHCBP1 (Shc SH2-domain binding protein 1) is a member of the Src and collagen homolog (Shc) protein family and is closely associated with multiple signaling pathways that play important roles during hair follicle induction, morphogenesis, and cycling. The purpose of this study was to investigate SHCBP1 gene expression, polymorphisms, and the association between SHCBP1 and wool quality traits in Chinese Merino sheep. The SHCBP1 gene was shown, by qPCR, to be ubiquitously expressed in sheep tissues and differentially expressed in the adult skin of Chinese Merino and Suffolk sheep. Four SNPs (termed SHCBP1SNPs 1-4) were identified by Sanger sequencing and were located in exon 2, intron 9, intron 12, and exon 13 of the sheep SHCBP1 gene, respectively. SHCBP1SNPs 3 and 4 (rs411176240 and rs160910635) were significantly associated with wool crimp (P < 0.05). The combined polymorphism (SHCBP1SNP3-SHCBP1SNP4) was significantly associated with wool crimp (P < 0.05). Bioinformatics analysis showed that the SNPs associated with wool crimp (SHCBP1SNPs 3 and 4) might affect the pre-mRNA splicing by creating binding sites for serine-arginine-rich proteins and that SHCBP1SNP4 might alter the SHCBP1 mRNA and protein secondary structure. Our results suggest that SHCBP1 influences wool crimp and SHCBP1SNPs 3 and 4 might be useful markers for marker-assisted selection and sheep breeding.
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