Effects of INSL3 and WNT2B gene polymorphisms on seasonal reproductive traits of Xinjiang Qira black sheep, Kazakh sheep and Duolang sheep
文献类型： 外文期刊
作者： Bi, Jingdong 1 ; Yiming, Sulaiman 1 ; Li, Jiaqi 1 ; Wang, Quanfeng 3 ; Zhai, Manjun 1 ; Cao, Shaoqi 4 ; Zhu, Mengting 1 ; Yang, Hua 2 ;
作者机构： 1.Xinjiang Agr Univ, Coll Anim Sci, Urumqi, Peoples R China
2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China
3.Husb Technol Co Ltd, Xinjiang Jinken Aoqun Agr & Anim, Yutian, Peoples R China
4.Xinjiang Uygur Autonomous Reg Anim Husb Gen Stn, Urumqi, Peoples R China
关键词： Sheep (Ovis aries); seasonal reproduction; litter size; INSL3; WNT2B
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：1.8； 五年影响因子：2.0 ）
ISSN： 1049-5398
年卷期： 2025 年 36 卷 1 期
页码：
收录情况： SCI
摘要： The purpose of this study was to investigate the polymorphism and genetic correlation of INSL3 and WNT2B genes with seasonal estrus and litter size in three different Xinjiang sheep breeds. The genetic diversity of INSL3 and WNT2B genes were analyzed, and their association with litter size and estrous traits were analyzed. The results showed that two SNPs (SNP1, SNP2) were detected in INSL3 gene and there were three genotypes in SNP2 (INSL3 (A100T)), named of AA, AT and TT, A was the dominant allele. Additionally, five SNPs (SNP3, SNP4, SNP5, SNP6, SNP7) were detected in the WNT2B gene and there were three genotypes in SNP4 (WNT2B (G126T)), named GG, GT and TT, G was dominant allele. SNP2 was in Hardy-Weinberg equilibrium in three sheep breeds (P > 0.05). SNP4 was deviated from Hardy-Weinberg equilibrium in three sheep breeds (P < 0.05). Further, AT genotype of SNP2 (INSL3 (A100T)) could significantly affect the estrus trait in Duolang sheep and Qira black sheep, and related to the litter size in Duolang sheep. The WNT2B significantly affected the estrus and litter size of Duolang sheep and Qira black sheep. INSL3 (A100T) and WNT2B (G126T) may be potential molecular markers for controlling seasonal reproductive trait in sheep.
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