Uncovering the candidate genes related to sheep body weight using multi-trait genome-wide association analysis
文献类型： 外文期刊
作者： Li, Yunna 1 ; Yang, Hua 2 ; Guo, Jing 1 ; Yang, Yonglin 2 ; Yu, Qian 2 ; Guo, Yuanyuan 1 ; Zhang, Chaoxin 1 ; Wang, Zhipeng 1 ; Zuo, Peng 2 ;
作者机构： 1.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin, Peoples R China
2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China
3.Northeast Agr Univ, Coll Sci, Harbin, Peoples R China
关键词： sheep; body weight; genome-wide association analysis; multi-trait; single-trait
期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.2； 五年影响因子：3.5 ）
ISSN：
年卷期： 2023 年 10 卷
页码：
收录情况： SCI
摘要： In sheep, body weight is an economically important trait. This study sought to map genetic loci related to weaning weight and yearling weight. To this end, a single-trait and multi-trait genome-wide association study (GWAS) was performed using a high-density 600 K single nucleotide polymorphism (SNP) chip. The results showed that 43 and 56 SNPs were significantly associated with weaning weight and yearling weight, respectively. A region associated with both weaning and yearling traits (OARX: 6.74-7.04 Mb) was identified, suggesting that the same genes could play a role in regulating both these traits. This region was found to contain three genes (TBL1X, SHROOM2 and GPR143). The most significant SNP was Affx-281066395, located at 6.94 Mb (p = 1.70 x 10(-17)), corresponding to the SHROOM2 gene. We also identified 93 novel SNPs elated to sheep weight using multi-trait GWAS analysis. A new genomic region (OAR10: 76.04-77.23 Mb) with 22 significant SNPs were discovered. Combining transcriptomic data from multiple tissues and genomic data in sheep, we found the HINT1, ASB11 and GPR143 genes may involve in sheep body weight. So, multi-omic anlaysis is a valuable strategy identifying candidate genes related to body weight.
- 相关文献
作者其他论文 更多>>
-
Design of label-free electrochemical aptasensors for enrofloxacin detection in mutton
作者：Yu, Qian;Yang, Yonglin
关键词：Aptasensor; Enrofloxacin; Impedimetric; Label-free; Mutton; Nanocomposite
-
Genome-wide comparative analysis reveals selection signatures for reproduction traits in prolific Suffolk sheep
作者：Yang, Hua;Zhu, Mengting;Wang, Mingyuan;Zhou, Huaqian;Zheng, Jingjing;Qiu, Lixia;Fan, Wenhua;Yang, Jinghui;Yu, Qian;Yang, Yonglin;Zhang, Wenzhe;Zhu, Mengting;Wang, Mingyuan;Zhou, Huaqian;Zheng, Jingjing;Fan, Wenhua
关键词：selection signatures; fst; reproduction traits; candidate genes; sheep
-
Whole-genome resequencing of the native sheep provides insights into the microevolution and identifies genes associated with reproduction traits
作者：Zhu, Mengting;Yang, Yonglin;Yang, Hua;Wang, Mingyuan;Yu, Qian;Zhu, Mengting;Zhao, Zongsheng;Zheng, Wei;Wang, Mingyuan;Fang, Chenhui;Zhou, Huaqian;Qi, Hangdong;Zhang, Hongmei;Blair, Hugh T.
关键词：Microevolution; Selection signature; Whole-genome resequencing; GWAS; Reproductive trait; Sheep
-
Fabrication of an electrochemical sensor for the rapid and sensitive detection of enrofloxacin in meat samples
作者：Yu, Qian;Yang, Hua;Yang, Yonglin
关键词：Enrofloxacin; Electrochemical Detection; Cobalt-based Hybrid Modified Carbon-Based Electrode; Food Safety; Antibiotics detection
-
Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci
作者：Lv, Feng-Hua;Luo, Ling-Yun;Lu, Ran;Chen, Jian-Fei;Wang, Jian-Kui;Deng, Xue-Mei;Dehghani-Qanatqestani, Mostafa;Li, Meng-Hua;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Liu, Guang-Jian;Liu, Ming-Jun;Li, Wen-Rong;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Ren, Yan-Ling;Shen, Zhi-Qiang;Wang, Feng;Wang, Yu-Tao;Li, Jin-Quan;Hehua, Eer;Liu, Yong-Gang;Esmailizadeh, Ali;Dehghani-Qanatqestani, Mostafa;Charati, Hadi;Rushdi, Hossam E.;Nosrati, Maryam;Stepanek, Ondrej;Olsaker, Ingrid;Curik, Ino;Gorkhali, Neena A.;Paiva, Samuel R.;Caetano, Alexandre R.;Ciani, Elena;Amills, Marcel;Amills, Marcel;Weimann, Christina;Erhardt, Georg;Amane, Agraw;Amane, Agraw;Hanotte, Olivier;Mwacharo, Joram M.;Mwacharo, Joram M.;Mwacharo, Joram M.;Han, Jian-Lin;Han, Jian-Lin;Hanotte, Olivier;Periasamy, Kathiravan;Johansson, Anna M.;Hallsson, Jon H.;Kantanen, Juha;Coltman, David W.;Bruford, Michael W.;Bruford, Michael W.;Lenstra, Johannes A.
关键词：whole-genome sequences; genetic diversity; adaptive introgression; genetic selection; agronomic traits; migration
-
Targeting GNAQ in hypothalamic nerve cells to regulate seasonal estrus in sheep
作者：Zhu, Mengting;Yang, Hua;Yu, Qian;Zhu, Mengting;Zhao, Zongsheng;Liang, Huihui;Wu, Pei;Zhang, Hongmei;Blair, Hugh T.
关键词：Kazakh sheep; Seasonal estrus; GNAQ; Hypothalamic nerve cells; GnRH
-
Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci
作者：Lv, Feng-Hua;Luo, Ling-Yun;Lu, Ran;Chen, Jian-Fei;Wang, Jian-Kui;Deng, Xue-Mei;Dehghani-Qanatqestani, Mostafa;Li, Meng-Hua;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Liu, Guang-Jian;Liu, Ming-Jun;Li, Wen-Rong;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Ren, Yan-Ling;Shen, Zhi-Qiang;Wang, Feng;Wang, Yu-Tao;Li, Jin-Quan;Hehua, Eer;Liu, Yong-Gang;Esmailizadeh, Ali;Dehghani-Qanatqestani, Mostafa;Charati, Hadi;Rushdi, Hossam E.;Nosrati, Maryam;Stepanek, Ondrej;Olsaker, Ingrid;Curik, Ino;Gorkhali, Neena A.;Paiva, Samuel R.;Caetano, Alexandre R.;Ciani, Elena;Amills, Marcel;Amills, Marcel;Weimann, Christina;Erhardt, Georg;Amane, Agraw;Amane, Agraw;Hanotte, Olivier;Mwacharo, Joram M.;Mwacharo, Joram M.;Mwacharo, Joram M.;Han, Jian-Lin;Han, Jian-Lin;Hanotte, Olivier;Periasamy, Kathiravan;Johansson, Anna M.;Hallsson, Jon H.;Kantanen, Juha;Coltman, David W.;Bruford, Michael W.;Bruford, Michael W.;Lenstra, Johannes A.
关键词：whole-genome sequences; genetic diversity; adaptive introgression; genetic selection; agronomic traits; migration
