Genome-wide comparative analysis reveals selection signatures for reproduction traits in prolific Suffolk sheep
文献类型： 外文期刊
作者： Yang, Hua 1 ; Zhu, Mengting 1 ; Wang, Mingyuan 1 ; Zhou, Huaqian 1 ; Zheng, Jingjing 1 ; Qiu, Lixia 1 ; Fan, Wenhua 1 ; Yang, Jinghui 1 ; Yu, Qian 1 ; Yang, Yonglin 1 ; Zhang, Wenzhe 1 ;
作者机构： 1.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China
2.Xinjiang Agr Univ, Coll Anim Sci, Urumqi, Peoples R China
3.Shihezi Univ, Coll Anim Sci & Technol, Shihezi, Peoples R China
关键词： selection signatures; fst; reproduction traits; candidate genes; sheep
期刊名称：FRONTIERS IN GENETICS （ 影响因子：2.8； 五年影响因子：3.3 ）
ISSN：
年卷期： 2024 年 15 卷
页码：
收录情况： SCI
摘要： The identification of genome-wide selection signatures can reveal the potential genetic mechanisms involved in the generation of new breeds through natural or artificial selection. In this study, we screened the genome-wide selection signatures of prolific Suffolk sheep, a new strain of multiparous mutton sheep, to identify candidate genes for reproduction traits and unravel the germplasm characteristics and population genetic evolution of this new strain of Suffolk sheep. Whole-genome resequencing was performed at an effective sequencing depth of 20x for genomic diversity and population structure analysis. Additionally, selection signatures were investigated in prolific Suffolk sheep, Suffolk sheep, and Hu sheep using fixation index (F ST) and heterozygosity H) analysis. A total of 5,236.338 Gb of high-quality genomic data and 28,767,952 SNPs were obtained for prolific Suffolk sheep. Moreover, 99 selection signals spanning candidate genes were identified. Twenty-three genes were significantly associated with KEGG pathway and Gene Ontology terms related to reproduction, growth, immunity, and metabolism. Through selective signal analysis, genes such as ARHGEF4, CATIP, and CCDC115 were found to be significantly correlated with reproductive traits in prolific Suffolk sheep and were highly associated with the mTOR signaling pathway, the melanogenic pathway, and the Hippo signaling pathways, among others. These results contribute to the understanding of the evolution of artificial selection in prolific Suffolk sheep and provide candidate reproduction-related genes that may be beneficial for the establishment of new sheep breeds.
- 相关文献
作者其他论文 更多>>
-
Design of label-free electrochemical aptasensors for enrofloxacin detection in mutton
作者：Yu, Qian;Yang, Yonglin
关键词：Aptasensor; Enrofloxacin; Impedimetric; Label-free; Mutton; Nanocomposite
-
Whole-genome resequencing of the native sheep provides insights into the microevolution and identifies genes associated with reproduction traits
作者：Zhu, Mengting;Yang, Yonglin;Yang, Hua;Wang, Mingyuan;Yu, Qian;Zhu, Mengting;Zhao, Zongsheng;Zheng, Wei;Wang, Mingyuan;Fang, Chenhui;Zhou, Huaqian;Qi, Hangdong;Zhang, Hongmei;Blair, Hugh T.
关键词：Microevolution; Selection signature; Whole-genome resequencing; GWAS; Reproductive trait; Sheep
-
Fabrication of an electrochemical sensor for the rapid and sensitive detection of enrofloxacin in meat samples
作者：Yu, Qian;Yang, Hua;Yang, Yonglin
关键词：Enrofloxacin; Electrochemical Detection; Cobalt-based Hybrid Modified Carbon-Based Electrode; Food Safety; Antibiotics detection
-
Uncovering the candidate genes related to sheep body weight using multi-trait genome-wide association analysis
作者：Li, Yunna;Guo, Jing;Guo, Yuanyuan;Zhang, Chaoxin;Wang, Zhipeng;Li, Yunna;Yang, Hua;Guo, Jing;Yang, Yonglin;Yu, Qian;Guo, Yuanyuan;Zhang, Chaoxin;Wang, Zhipeng;Zuo, Peng;Zuo, Peng
关键词：sheep; body weight; genome-wide association analysis; multi-trait; single-trait
-
Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci
作者：Lv, Feng-Hua;Luo, Ling-Yun;Lu, Ran;Chen, Jian-Fei;Wang, Jian-Kui;Deng, Xue-Mei;Dehghani-Qanatqestani, Mostafa;Li, Meng-Hua;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Liu, Guang-Jian;Liu, Ming-Jun;Li, Wen-Rong;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Ren, Yan-Ling;Shen, Zhi-Qiang;Wang, Feng;Wang, Yu-Tao;Li, Jin-Quan;Hehua, Eer;Liu, Yong-Gang;Esmailizadeh, Ali;Dehghani-Qanatqestani, Mostafa;Charati, Hadi;Rushdi, Hossam E.;Nosrati, Maryam;Stepanek, Ondrej;Olsaker, Ingrid;Curik, Ino;Gorkhali, Neena A.;Paiva, Samuel R.;Caetano, Alexandre R.;Ciani, Elena;Amills, Marcel;Amills, Marcel;Weimann, Christina;Erhardt, Georg;Amane, Agraw;Amane, Agraw;Hanotte, Olivier;Mwacharo, Joram M.;Mwacharo, Joram M.;Mwacharo, Joram M.;Han, Jian-Lin;Han, Jian-Lin;Hanotte, Olivier;Periasamy, Kathiravan;Johansson, Anna M.;Hallsson, Jon H.;Kantanen, Juha;Coltman, David W.;Bruford, Michael W.;Bruford, Michael W.;Lenstra, Johannes A.
关键词：whole-genome sequences; genetic diversity; adaptive introgression; genetic selection; agronomic traits; migration
-
Targeting GNAQ in hypothalamic nerve cells to regulate seasonal estrus in sheep
作者：Zhu, Mengting;Yang, Hua;Yu, Qian;Zhu, Mengting;Zhao, Zongsheng;Liang, Huihui;Wu, Pei;Zhang, Hongmei;Blair, Hugh T.
关键词：Kazakh sheep; Seasonal estrus; GNAQ; Hypothalamic nerve cells; GnRH
-
Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci
作者：Lv, Feng-Hua;Luo, Ling-Yun;Lu, Ran;Chen, Jian-Fei;Wang, Jian-Kui;Deng, Xue-Mei;Dehghani-Qanatqestani, Mostafa;Li, Meng-Hua;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Liu, Guang-Jian;Liu, Ming-Jun;Li, Wen-Rong;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Ren, Yan-Ling;Shen, Zhi-Qiang;Wang, Feng;Wang, Yu-Tao;Li, Jin-Quan;Hehua, Eer;Liu, Yong-Gang;Esmailizadeh, Ali;Dehghani-Qanatqestani, Mostafa;Charati, Hadi;Rushdi, Hossam E.;Nosrati, Maryam;Stepanek, Ondrej;Olsaker, Ingrid;Curik, Ino;Gorkhali, Neena A.;Paiva, Samuel R.;Caetano, Alexandre R.;Ciani, Elena;Amills, Marcel;Amills, Marcel;Weimann, Christina;Erhardt, Georg;Amane, Agraw;Amane, Agraw;Hanotte, Olivier;Mwacharo, Joram M.;Mwacharo, Joram M.;Mwacharo, Joram M.;Han, Jian-Lin;Han, Jian-Lin;Hanotte, Olivier;Periasamy, Kathiravan;Johansson, Anna M.;Hallsson, Jon H.;Kantanen, Juha;Coltman, David W.;Bruford, Michael W.;Bruford, Michael W.;Lenstra, Johannes A.
关键词：whole-genome sequences; genetic diversity; adaptive introgression; genetic selection; agronomic traits; migration
