First identification and genomic characterization of equine hepacivirus subtype 2 in China
文献类型： 外文期刊
作者： Chen, Yuxin 1 ; Cai, Siqi 1 ; Zhang, Ying 4 ; Lai, Zhiying 1 ; Zhong, Lintao 1 ; Sun, Xingrong 5 ; Li, Shoujun 1 ; Lu, Ga 1 ;
作者机构： 1.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China
2.Guangdong Prov Key Lab Prevent & Control Severe C, Guangzhou 510642, Guangdong, Peoples R China
3.Guangdong Technol Engn Res Ctr Pet, Guangzhou 510642, Guangdong, Peoples R China
4.Guangdong Polytech Sci & Trade, Coll Anim Sci & Technol, Guangzhou 510642, Guangdong, Peoples R China
5.Heilongjiang Acad Agr Sci, Daqing Branches, Daqing 163316, Heilongjiang, Peoples R China
期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）
ISSN： 0304-8608
年卷期： 2021 年 166 卷 11 期
页码：
收录情况： SCI
摘要： Equine hepacivirus (EqHV) is a newly discovered hepatitis C virus-like virus that can infect equines. EqHV strains circulating worldwide have been classified into subtypes 1-3. In previous studies, we detected the presence of EqHV strains of subtype 1 and 3 in China. To determine whether EqHV strains of subtype 2 are prevalent in China, serum samples were collected from 133 racehorses in Guangdong province in 2021 and were tested for EqHV RNA by RT-PCR, and the positive rate was 9% (12/133). Sequencing of the NS3 gene revealed that one field strain (GD2021) had a high degree of genetic similarity to EqHV strains of subtype 2. Subsequent genome sequencing and analysis demonstrated that strain GD2021 belongs to subtype 2. The present study enriches our knowledge about the genetic diversity of EqHV in China.
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