Discovery, Characterization, and Application of Broad-Spectrum Antimicrobial Peptide AtR905 from Aspergillus terreus as a Biocontrol Agent
文献类型： 外文期刊
作者： Zhao, Yang 1 ; Liu, Fang 1 ; Lan, Xing 2 ; Xu, Wenxing 2 ; Dong, Wubei 2 ; Ke, Shaoyong 1 ; Wu, Hongqu 1 ;
作者机构： 1.Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Hubei Biopesticide Engn Res Ctr, Minist Agr & Rural Affairs,Key Lab Microbial Pest, Wuhan 430064, Peoples R China
2.Huazhong Agr Univ, Coll Plant Sci & Technol, Wuhan 430070, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Microbial Pesticides, Wuhan 430070, Peoples R China
关键词：
antimicrobial peptide; endophyte;
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2024 年 73 卷 5 期
页码：
收录情况： SCI
摘要： This study investigates a novel antimicrobial peptide AtR905 derived from the endophytic fungus Aspergillus terreus, which was successfully expressed in Bacillus subtilis, purified, and characterized, and highlighted as a promising potential biocontrol agent against various plant pathogens. The results indicated AtR905 exhibited broad-spectrum antimicrobial activities against key pathogens such as Ralstonia solanacearum and Clavibacter michiganensis with very low minimal inhibitory concentrations (MICs). Stability tests confirmed that AtR905 retains its antimicrobial properties under varying thermal, pH, and UV conditions. The Oxford Cup test indicated that AtR905 showed obvious fungicidal activity against six plant pathogenic fungi, especially Rhizoctonia solani and Botrytis cinerea. Additionally, in vivo experimental demonstrated AtR905 could effectively control the B. cinerea on tobacco leaves and R. solanacearum on tomato plants. Scanning electron microscopy revealed significant membrane disruption in bacterial cells treated with AtR905. These findings suggest that AtR905 is a promising candidate for sustainable plant disease management, potentially reducing the reliance on chemical pesticides and mitigating the issue of antibiotic resistance in agricultural settings. Further research is needed to evaluate the long-term field applicability and ecological impacts of AtR905.
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