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A small antimicrobial peptide derived from a Burkholderia bacterium exhibits a broad-spectrum and high inhibiting activities against crop diseases

文献类型： 外文期刊

作者： Mohamed, Gamarelanbia 1 ; Ji, Ao 1 ; Cao, Xinyu 1 ; Islam, Md. Samiul 3 ; Hassan, Mohamed F. 3 ; Zhao, Yang 3 ; Lan, Xing 3 ; Dong, Wubei 3 ; Wu, Hongqu 1 ; Xu, Wenxing 1 ;

作者机构： 1.Natl Key Lab Germplasm Innovat & Utilizat Hort Cro, Wuhan, Peoples R China

2.Huazhong Agr Univ, Hubei Hongshan Lab, Wuhan, Peoples R China

3.Huazhong Agr Univ, Coll Plant Sci & Technol, Wuhan, Peoples R China

4.Key Lab Plant Pathol Hubei Prov, Wuhan, Peoples R China

5.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan, Peoples R China

关键词： crop disease; plant protection; biocontrol; antimicrobial peptide; antagonistic bacteria; antibiotics

期刊名称：PLANT BIOTECHNOLOGY JOURNAL （ 影响因子：10.5； 五年影响因子：12.4 ）

ISSN： 1467-7644

年卷期： 2025 年 23 卷 2 期

页码：

收录情况： SCI

摘要： Crop diseases cause significant quality and yield losses to global crop products each year and are heavily controlled by chemicals along with very limited antibiotics composed of small molecules. However, these methods often result in environmental pollution and pest resistance, necessitating the development of new bio-controlling products to mitigate these hazards. To identify effective antimicrobial peptides (AMPs) considered as potential sources of future antibiotics, AMPs were screened from five bacterial strains showing antagonism against a representative phytopathogenic fungus (Rhizoctonia Solani) through the Bacillus subtilis expression system, which has been developed for identifying bacterial AMPs by displaying autolysis morphologies. A total of 5000 colonies were screened, and five displaying autolysis morphologies showed antagonism against R. solani. A novel AMP with the strongest antagonism efficiency was determined and tentatively named HR2-7, which is composed of 24 amino acids with an alpha-helical structure. HR2-7 has strong and broad-spectrum antimicrobial activity, tested against 10 g-positive and -negative bacteria and four phytopathogenic fungi by contact culture in plates with minimal lethal concentrations of 4.0 mu M. When applied as purified peptide or in fermented B. subtilis culture solution, HR2-7 showed strong controlling efficiency on plants against diverse fungal and bacterial pathogens. Based on current understanding, HR2-7 is recognized as the first AMP derived from an agricultural antagonistic bacterium. It exhibits wide-ranging and notable antimicrobial efficacy, offering a supplementary approach for managing plant diseases, in addition to conventional chemical pesticides and antibiotics.

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