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Mechanistic insights into citral-induced cellular damage and its antibacterial efficacy against Listeria monocytogenes

文献类型： 外文期刊

作者： Dai, Jinming 1 ; Bai, Mei 2 ; Fang, Houzhi 1 ; Aziz, Tariq 1 ; Shami, Ashwag 3 ; Al-Asmari, Fahad 4 ; Al-Joufi, Fakhria A. 5 ; Alwethaynani, Maher S. 6 ; Cui, Haiying 1 ;

作者机构： 1.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

2.Jiangsu Acad Agr Sci, Jiangsu Key Lab Food Qual & Safety State Key Lab C, Nanjing 210014, Peoples R China

3.Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Biol, POB 84428, Riyadh 11671, Saudi Arabia

4.King Faisal Univ, Coll Agr & Food Sci, Dept Food & Nutr Sci, Al Hasa 31982, Saudi Arabia

5.Jouf Univ, Coll Pharm, Dept Pharmacol, Aljouf 72341, Saudi Arabia

6.Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Riyadh 11911, Saudi Arabia

关键词： Citral; Listeria monocytogenes; Antibacterial mechanism; Membrane depolarization; Oxidative stress

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）

ISSN： 2212-4292

年卷期： 2025 年 68 卷

页码：

收录情况： SCI

摘要： Citral is widely recognized as a membrane-targeting antimicrobial, with its bactericidal activity primarily dependent on the degree of membrane damage. This study reveals its dual mechanism involving oxidative assault against Listeria monocytogenes (L. monocytogenes). The induced cytotoxic effects appear closely associated with citral's interaction with bacterial cell membrane components and the resultant sustained membrane dysfunction. Our results showed that sublethal concentrations of citral induced rapid depolarization in L. monocytogenes while progressively increasing membrane permeability. Following 1 h of citral exposure, the intracellular generation of reactive oxygen species peaked. Further investigations indicated that citral could directly interact with and alter the chemical structure of reduced glutathione (GSH). Notably, exogenous GSH supplementation significantly attenuated citral's antimicrobial efficacy, suggesting that its biochemical reactivity targeting glutathione and related thiol-containing proteins plays a critical role in the antibacterial action against L. monocytogenes. Importantly, regardless of growth inhibition, all tested concentrations of citral significantly suppressed the hemolytic activity of L. monocytogenes. Overall, this study provides valuable insights into the antimicrobial mechanisms of citral, particularly at low concentrations.

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