Fine Mapping of QTLs for Alkaline Tolerance in Crucian Carp (Carassius auratus) Using Genome-Wide SNP Markers
文献类型： 外文期刊
作者： Zhang, Liang 1 ; Su, Baofeng 2 ; Huang, Jing 2 ; Zhang, Limin 2 ; Chang, Yumei 2 ; Hu, Guo 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, Heilongjiang River Fisheries Res Inst, Key Lab Freshwater Aquat Biotechnol & Breeding, Harbin 150070, Peoples R China
2.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Key Lab Fish Stress Resistance Breeding & Germplas, Harbin 150070, Peoples R China
3.Auburn Univ, Sch Fisheries Aquaculture & Aquat Sci, Auburn, AL 36849 USA
关键词： crucian carp; genetic linkage map; QTL mapping; alkali-tolerant fish
期刊名称：GENES （ 影响因子：2.8； 五年影响因子：3.3 ）
ISSN：
年卷期： 2024 年 15 卷 6 期
页码：
收录情况： SCI
摘要： Crucian carp (Carassius auratus) is widely distributed in the world and has become an economically freshwater fish. The population in Lake Dali Nur can tolerate the extreme alkaline environment with alkalinity over 50 mmol/L (pH 9.6), thus providing a special model for exploring alkali-tolerant molecular markers in an extremely alkaline environment. In this study, we constructed a high-density and high-resolution linkage map with 16,224 SNP markers based on genotyping-by-sequencing (GBS) consisting of 152 progenies and conducted QTL studies for alkali-tolerant traits. The total length of the linkage map was 3918.893 cM, with an average distance of 0.241 cM. Two QTLs for the ammonia-N-tolerant trait were detected on LG27 and LG45. A QTL for the urea-N-tolerant trait was detected on LG27. Interestingly, mapping the two QTLs on LG27 revealed that the mapped genes were both located in the intron of CDC42. GO functional annotation and KEGG enrichment analysis results indicated that the biological functions might be involved in the cell cycle, cellular senescence, MAPK, and Ras signaling pathways. These findings suggest that CDC42 may play an important role in the process of dealing with extremely alkaline environments.
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