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Eurycomanone (EN) Activates Transcription Factor FoxO by Inhibiting the Insulin Signaling Pathway to Suppress the Development of Spodoptera frugiperda

文献类型： 外文期刊

作者： Zhang, Jie 1 ; Wu, Siyu 1 ; Wen, Yingjie 1 ; Lai, Duo 1 ; Kuang, Shizi 1 ; Zhang, Ruonan 2 ; Xu, Xiaoxia 2 ; Jin, Fengliang 2 ; Xu, Hanhong 2 ; Yu, Xiao-Qiang 3 ; Shao, Xuehua 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Fruit Tree Res, Key Lab South Subtrop Fruit Biol & Genet Resource, Guangdong Prov Key Lab Trop & Subtrop Fruit Tree R, Guangzhou 510640, Peoples R China

2.South China Agr Univ, Coll Plant Protect, Natl Key Lab Green Pesticide, Guangzhou 510642, Peoples R China

3.South China Normal Univ, Inst Insect Sci & Technol, Sch Life Sci, Guangdong Prov Key Lab Insect Dev Biol & Appl Tech, Guangzhou, Peoples R China

关键词： Spodoptera frugiperda; insulin-like signaling; FoxO; eurycomanone; botanical pesticide; nutrition catabolism

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2023 年 71 卷 27 期

页码：

收录情况： SCI

摘要： The insulin-like signaling (IIS)pathway is essentialfor insectgrowth and development. In this study, we showed that eurycomanone(EN) is an active compound with growth inhibitory activity against Spodoptera frugiperda larvae. Experiments in cellsand RNA-seq analysis in the midgut showed that EN targeted the IISpathway in S. frugiperda to activatethe transcription factor SfFoxO (S. frugiperda forkhead boxO) to regulate mRNA levels associated with nutrientcatabolism. Additionally, mass spectrometry imaging revealed thatEN was distributed in the larval gut and enriched in the inner membraneof the gut. Immunofluorescence, western blotting, and quantitativereverse transcription-polymerase chain reaction (qRT-PCR) resultsshowed that EN induced program cell death (PCD) in the larvae midgut.Thus, EN targeted the insulin receptor to inhibit the IIS signalingpathway, exerting inhibitory activity on the growth and developmentof S. frugiperda larvae. Our resultssuggest that EN has great potential as a botanical pesticide, andthe IIS signaling pathway may be an effective target for botanicalpesticides.

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