Eurycomanone (EN) Activates Transcription Factor FoxO by Inhibiting the Insulin Signaling Pathway to Suppress the Development of Spodoptera frugiperda
文献类型： 外文期刊
作者： Zhang, Jie 1 ; Wu, Siyu 1 ; Wen, Yingjie 1 ; Lai, Duo 1 ; Kuang, Shizi 1 ; Zhang, Ruonan 2 ; Xu, Xiaoxia 2 ; Jin, Fengliang 2 ; Xu, Hanhong 2 ; Yu, Xiao-Qiang 3 ; Shao, Xuehua 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Inst Fruit Tree Res, Key Lab South Subtrop Fruit Biol & Genet Resource, Guangdong Prov Key Lab Trop & Subtrop Fruit Tree R, Guangzhou 510640, Peoples R China
2.South China Agr Univ, Coll Plant Protect, Natl Key Lab Green Pesticide, Guangzhou 510642, Peoples R China
3.South China Normal Univ, Inst Insect Sci & Technol, Sch Life Sci, Guangdong Prov Key Lab Insect Dev Biol & Appl Tech, Guangzhou, Peoples R China
关键词： Spodoptera frugiperda; insulin-like signaling; FoxO; eurycomanone; botanical pesticide; nutrition catabolism
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）
ISSN： 0021-8561
年卷期： 2023 年 71 卷 27 期
页码：
收录情况： SCI
摘要： The insulin-like signaling (IIS)pathway is essentialfor insectgrowth and development. In this study, we showed that eurycomanone(EN) is an active compound with growth inhibitory activity against Spodoptera frugiperda larvae. Experiments in cellsand RNA-seq analysis in the midgut showed that EN targeted the IISpathway in S. frugiperda to activatethe transcription factor SfFoxO (S. frugiperda forkhead boxO) to regulate mRNA levels associated with nutrientcatabolism. Additionally, mass spectrometry imaging revealed thatEN was distributed in the larval gut and enriched in the inner membraneof the gut. Immunofluorescence, western blotting, and quantitativereverse transcription-polymerase chain reaction (qRT-PCR) resultsshowed that EN induced program cell death (PCD) in the larvae midgut.Thus, EN targeted the insulin receptor to inhibit the IIS signalingpathway, exerting inhibitory activity on the growth and developmentof S. frugiperda larvae. Our resultssuggest that EN has great potential as a botanical pesticide, andthe IIS signaling pathway may be an effective target for botanicalpesticides.
- 相关文献
作者其他论文 更多>>
-
Transcriptomic Responses of Litchi to the Application of Exogenous Melanin Under Cold Stress
作者：Shi, Fachao;Jiang, Yonghua;Liu, Hailun;Wen, Yingjie;Yan, Qian
关键词：RNA-seq; melatonin; cold stress; litchi seedlings; gene expression
-
Hsp70-mediated manipulation of antimicrobial peptide-related genes promotes BmNPV proliferation in Bombyx mori at relatively high temperatures
作者：Zhang, Jie;Hu, Yingying;Feng, Jiawei;He, Na;Li, Xiaofeng;Liyi, Qingge;Yi, Huiyu;Yang, Wanying;Zhang, Jie;Yang, Qiong
关键词：Bombyx mori; BmNPV; Innate immunity; Host-pathogen interaction; Heat shock protein (Hsp); Antimicrobial peptide (AMP)
-
pH/Enzyme-responsive nanocarrier pesticide delivery system: Realizing targeted release in pest gut for enhanced Apis cerana safety
作者：Du, Pengrui;Wu, Hao;Hou, Ruiquan;Liu, Jun;Chang, Jinzhe;Miao, Xiaoran;Wang, Xin;Liu, Pengpeng;Zhu, Shiqi;Zhang, Zhixiang;Zhang, Peiwen;Shao, Xuehua;Kaziem, Amir E.;Zhang, Peiwen
关键词：Zein; O-carboxymethyl chitosan; Environmentally responsive; Controlled-release pesticide; Biological safety
-
Herbivore-induced maize volatiles: dual functions in repelling fall armyworm and attracting natural enemies
作者：Wang, Jiali;Yi, Ting;Wang, Manwen;Wei, Jiaqi;Yan, Wenjuan;Wen, Yingjie;Zeng, Lingda;Xu, Hanhong;Wang, Jiali;Wen, Yingjie
关键词：herbivore-induced plant volatiles (HIPVs); fall armyworm (FAW); natural enemy; oviposition inhibition; sustainable pest management
-
Guava root exudate-driven rhizosphere microorganisms changes transmitted to foliar-feeding insects influence their feeding behaviour
作者：Zhang, Peiwen;Shao, Xuehua;Zhang, Peiwen;Zhang, Zhixiang;Lu, Wei;Yue, Lei
关键词：guava; root exudates; rhizosphere microorganisms;
Spodoptera litura ; gut microorganisms -
Inhibition of Glucosinolate Sulfatases to Combat Plutella xylostella: Development of Novel Phenylcarboxamide Derivatives for Plant-Integrated Pest Management
作者：Wang, Jiali;Wang, Manwen;Wen, Yingjie;Zeng, Lingda;Xu, Hanhong;Ravi, Anil;Zaraei, Seyed-Omar;Alkubaisi, Bilal O.;El-Gamal, Mohammed I.;Wang, Jiali;Wen, Yingjie;Wen, Yingjie;El-Gamal, Mohammed I.;El-Gamal, Mohammed I.
关键词：
Plutella xylostella ; glucosinolatesulfatases; GSSs inhibitions; isothiocyanates; phenylcarboxamide derivatives; plant defense system -
Lipidomic profiling of guava cultivars by UPLC/MS Q-TOF analysis
作者：Shao, Xuehua;Lai, Duo;Xiao, Weiqiang;Zhuang, Qingli;Qin, Jian;Chen, Jun;Ning, Lin
关键词：Chain length; Chain unsaturation; Guava fruit; Lipidomic profiling; UPLC/MS Q-TOF
