Dityrosine Aggravates Hepatic Insulin Resistance in Obese Mice by Altering Gut Microbiota and the LPS/TLR4/NF-?B Inflammatory Pathway
文献类型： 外文期刊
作者： Ding, Yin-Yi 1 ; Lan, Jinchi 1 ; Fang, Yumeng 1 ; Pan, Yuxiang 1 ; Gu, Zhenyu 1 ; Xue, Jing 1 ; Yang, Ying 4 ; Jiang, Mengqi 5 ; Ge, Yujun 6 ; Shen, Qing 2 ;
作者机构： 1.Zhejiang Gongshang Univ, Food Nutr Sci Ctr, Sch Food Sci & Biotechnol, Food Safety Key Lab Zhejiang Prov, Hangzhou 310018, Peoples R China
2.Wenzhou Med Univ, Quzhou Affiliated Hosp, Quzhou Peoples Hosp, Dept Clin Lab, Quzhou 324000, Peoples R China
3.Zhejiang Gongshang Univ, Inst Seafood, Collaborat Innovat Ctr Seafood Deep Proc, Zhejiang Prov Joint Key Lab Aquat Prod Proc, Hangzhou 310018, Peoples R China
4.Inst Food Sci, Zhejiang Acad Agr Sci, Hangzhou 310021, Peoples R China
5.Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China
6.Cent blood Stn Jiaxing, Jiaxing 314000, Peoples R China
关键词： dityrosine; gut microbiota; HFD-induced obesity mice; insulin resistance; LPS/TLR4/NF-kappa B inflammatory pathway
期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：5.2； 五年影响因子：6.2 ）
ISSN： 1613-4125
年卷期： 2023 年
页码：
收录情况： SCI
摘要： Scope: Dityrosine is the main product of protein oxidation, which has been proved to be a threat to human health. This study aims to investigate whether dityrosine exacerbates insulin resistance by inducing gut flora disturbance and associated inflammatory responses. Methods and results: Mice fed with normal diet or high-fat diet (HFD) received daily gavage of dityrosine (320 mu g kg(-1) BW) or saline for consecutive 13 weeks. The effects of dityrosine on gut microbiota are verified by in vitro fermentation using fecal microbiota from db/m mice and db/db mice. As a result, dityrosine causes the insulin resistance in mice fed normal diet, and aggravates the effects of HFD on insulin sensitivity. Dityrosine increases the levels of lipopolysaccharide (LPS), lipopolysaccharide-binding protein (LBP), toll-like receptor 4 (TLR4), nuclear factor kappa-B (NF-kappa B), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8) but decreases levels of interleukin-10 (IL-10) in the plasma of CON and HFD-fed mice. The changes of gut flora composition caused by dityrosine are significantly correlated with the changes of inflammatory biomarkers. Conclusion: The effects of dityrosine on insulin resistance may be attributed to the reshaping of the gut microbiota composition and promoting the activity of the LPS/TLR4/NF-kappa B inflammatory pathway in HFD-induced obese individuals.
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