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Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation

文献类型： 外文期刊

作者： Hong, Linjun 1 ; Zang, Xupeng 1 ; Hu, Qun 1 ; He, Yanjuan 1 ; Xu, Zhiqian 1 ; Xie, Yanshe 1 ; Gu, Ting 1 ; Yang, Huaqiang 1 ; Yang, Jie 1 ; Shi, Junsong 1 ; Zheng, Enqin 1 ; Huang, Sixiu 1 ; Xu, Zheng 1 ; Liu, Dewu 1 ; Cai, Gengyuan 1 ; Li, Zicong 1 ; Wu, Zhenfang 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Guangzhou 510642, Peoples R China

3.Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China

4.Yunfu Subctr Guangdong Lab Lingnan Modern Agr, Yunfu 527300, Peoples R China

5.State Key Lab Livestock & Poultry Breeding, Guangzhou 510642, Peoples R China

关键词： Uterine luminal fluid; Extracellular vesicles; Nanomedicine materials; Implantation; MEP1B

期刊名称：JOURNAL OF NANOBIOTECHNOLOGY （ 影响因子：10.2； 五年影响因子：11.5 ）

ISSN：

年卷期： 2023 年 21 卷 1 期

页码：

收录情况： SCI

摘要： Most pregnancy losses worldwide are caused by implantation failure for which there is a lack of effective therapeutics. Extracellular vesicles are considered potential endogenous nanomedicines because of their unique biological functions. However, the limited supply of ULF-EVs prevents their development and application in infertility diseases such as implantation failure. In this study, pigs were used as a human biomedical model, and ULF-EVs were isolated from the uterine luminal. We comprehensively characterized the proteins enriched in ULF-EVs and revealed their biological functions in promoting embryo implantation. By exogenously supplying ULF-EVs, we demonstrated that ULF-EVs improve embryo implantation, suggesting that ULF-EVs are a potential nanomaterial to treat implantation failure. Furthermore, we identified that MEP1B is important in improving embryo implantation by promoting trophoblast cell proliferation and migration. These results indicated that ULF-EVs can be a potential nanomaterial to improve embryo implantation.

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