Protective efficacy of a DNA vaccine encoding capsid protein of porcine circovirus-like virus P1 against porcine circovirus 2 in mice
文献类型： 外文期刊
作者： Zhang, Dan 1 ; He, Kongwang 1 ; Wen, Libin 1 ; Fan, Hongjie 2 ;
作者机构： 1.Jiangsu Acad Agr Sci, Key Lab Vet Biol Engn & Technol, Natl Ctr Engn Res Vet Bioprod, Inst Vet Med,Minist Agr, Nanjing 210000, Jiangsu, Peoples R China
2.Nanjing Agr Univ, Coll Vet Med, Nanjing 210014, Jiangsu, Peoples R China
3.Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China
关键词： DNA vaccine; mice; porcine circovirus 2; porcine circovirus-like virus P1
期刊名称：MICROBIOLOGY AND IMMUNOLOGY （ 影响因子：1.955； 五年影响因子：1.917 ）
ISSN： 0385-5600
年卷期： 2018 年 62 卷 3 期
页码：
收录情况： SCI
摘要： The capsid protein is the major immunogenic protein of porcine circovirus 2 (PCV2). The nucleotide sequence of porcine circovirus-like virus P1 shares high homology with open reading frame (ORF) 2 of PCV2, and ORF1 of P1 encodes its structural protein. Mice were vaccinated twice intramuscularly with a plasmid expressing the P1 ORF1 protein (pcDNA3.1(+)-ORF1) at 2-week intervals. All animals vaccinated with pcDNA3.1(+)-ORF1 developed higher specific anti-P1 antibody levels, and had less PCV2 viremia and milder histopathological changes than PCV2-challenged mice in the control group. Our results show that the P1 DNA vaccine elicited immune responses against PCV2 infection in a mouse model.
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